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BIONANOTECHNOLOGY FOR BREAST AND PROSTATE CANCER

Award Number: F32CA110667
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/15/2005
PERIOD OF PERFORMANCE END DATE: 08/14/2008

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BIONANOTECHNOLOGY FOR BREAST AND PROSTATE CANCER - DESCRIPTION (provided by applicant): In this project we will exploit a bionanotechnology developed at City of Hope to link multiple copies of a growth factor activator peptide (e.g. Heregulin, Epidermal Growth Factor) to two or three-armed DNA struts. The system is self-assembling and takes advantage of the capacity of bacterial methyltransferases to serve as targeting devices that can covalently link fusion proteins to precise sites on DNA. The device thus formed is expected to inhibit HERS or EGFR kinase activation by blocking one or more of structural transitions leading to dimerization or oligomerization of the receptor. The devices display the growth factor ligand in a two dimensional array suitable for capture of multiple extracellular domains of the receptor. Moreover, they can be tracked by appropriately labeling the DNA and have the advantage of increased binding affinity due to the multivalent display of growth factors. Our preliminary results show that a device displaying multiple copies of the growth factor ligand heregulin can bind to cancer cells.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2007 ( Subtotal = $52,048 )
2007	2007	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	3	7/20/2007	NON-COMPETING CONTINUATION	$52,048
														Subtotal = $52,048

Issue Date FY: 2006 ( Subtotal = $50,428 )
2006	2006	BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE	1450 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	2	8/7/2006	NON-COMPETING CONTINUATION	$50,428
														Subtotal = $50,428

Issue Date FY: 2005 ( Subtotal = $48,296 )
2005	2005	CITY OF HOPE NATIONAL MEDICAL CENTER	1500 EAST DUARTE ROAD	DUARTE	CA	91010	LOS ANGELES	USA	Cancer Research Manpower	000	1	8/11/2005	NEW	$48,296
														Subtotal = $48,296

Grand Total All Awards = $150,772

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BIONANOTECHNOLOGY FOR BREAST AND PROSTATE CANCER

Award Number: F32CA110667

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/15/2005

PERIOD OF PERFORMANCE END DATE: 08/14/2008

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