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Mechanism of lentiviral inhibition by Mx2

Award Number: F32AI116263
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/13/2017
PERIOD OF PERFORMANCE END DATE: 02/12/2018

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Mechanism of lentiviral inhibition by Mx2 - ¿ DESCRIPTION (provided by applicant): HIV-1 encounters many obstacles to viral replication in the host cell, which is armed with an "intrinsic" immune system of antiviral factors with direct antiviral activity, including APOBEC3G, TRIM5alpha, Tetherin, SAMHD1, and Mx2. Our understanding of the mechanism by which these factors inhibit retroviral replication, and how they are evaded by certain viruses has accrued significantly, but is far from complete. Such knowledge could greatly aid the development of new animal models of human disease and novel therapeutic intervention. The goal of this project is to investigate the mechanistic basis fo inhibition of HIV-1 infection by the newly identified factor, Mx2. The first aim of this project is to identify the cellular requirements for the localization and antviral activity of Mx2. It is unknown how Mx2 interacts with the nuclear pore complex, how it may be involved in regulation of nuclear import, or how the localization of Mx2 at the nuclear pore drives its antiviral activity. Both targeted and non-biased approaches will be employed to precisely identify cellular factors important for the antiviral activity of Mx2. The second aim is to determie the nature of the interaction between Mx2 and the HIV-1 capsid. It is known that the capsid is the determinant of sensitivity or resistance to inhibition by Mx2, but the mechanistic basis for this interaction remains unknown. Independent but complementary biochemical and genetic approaches will be utilized to define the precise interface that determines the antiviral specificiy of Mx2. The knowledge gained by this project will provide an enhanced understanding of how Mx2 inhibits the early stages of HIV-1 infection and can be utilized to develop new, targeted anti-retroviral therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2019 ( Subtotal = -$6,006 )
2019	2016	AARON DIAMOND AIDS RESEARCH CENTER FOR THE CITY OF NEW YORK, INC., THE	455 FIRST AVE 7TH FL	NEW YORK	NY	10016	NEW YORK	USA	Allergy and Infectious Diseases Research	000	2	9/16/2019	NON-COMPETING CONTINUATION	-$6,006
														Subtotal = -$6,006

Issue Date FY: 2017 ( Subtotal = $63,078 )
2017	2017	ROCKEFELLER UNIVERSITY, THE	1230 YORK AVE	NEW YORK	NY	10065	NEW YORK	USA	Allergy and Infectious Diseases Research	000	3	2/15/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$63,078
														Subtotal = $63,078

Issue Date FY: 2016 ( Subtotal = $59,970 )
2016	2016	AARON DIAMOND AIDS RESEARCH CTR FOR THE CITY OF NY INC	455 FIRST AVENUE, 7TH FLOOR	NEW YORK-NEW YORK	NY	10016		USA	Allergy and Infectious Diseases Research	001	2	1/12/2016	NON-COMPETING CONTINUATION	$57,962
2016	2016	AARON DIAMOND AIDS RESEARCH CTR FOR THE CITY OF NY INC	455 FIRST AVENUE, 7TH FLOOR	NEW YORK-NEW YORK	NY	10016		USA	Allergy and Infectious Diseases Research	002	2	2/4/2016	NON-COMPETING CONTINUATION	$2,008
2016	2015	AARON DIAMOND AIDS RESEARCH CTR FOR THE CITY OF NY INC	455 FIRST AVENUE, 7TH FLOOR	NEW YORK-NEW YORK	NY	10016		USA	Allergy and Infectious Diseases Research	000	1	10/23/2015	NEW	$0
														Subtotal = $59,970

Issue Date FY: 2015 ( Subtotal = $56,042 )
2015	2015	AARON DIAMOND AIDS RESEARCH CTR FOR THE CITY OF NY INC	455 FIRST AVENUE, 7TH FLOOR	NEW YORK-NEW YORK	NY	10016		USA	Allergy and Infectious Diseases Research	002	1	1/12/2015	NEW	$0
2015	2015	AARON DIAMOND AIDS RESEARCH CTR FOR THE CITY OF NY INC	455 FIRST AVENUE, 7TH FLOOR	NEW YORK-NEW YORK	NY	10016		USA	Allergy and Infectious Diseases Research	001	1	1/12/2015	NEW	$948
2015	2015	AARON DIAMOND AIDS RESEARCH CTR FOR THE CITY OF NY INC	455 FIRST AVENUE, 7TH FLOOR	NEW YORK-NEW YORK	NY	10016		USA	Allergy and Infectious Diseases Research	000	1	12/15/2014	NEW	$55,094
														Subtotal = $56,042

Grand Total All Awards = $173,084

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Mechanism of lentiviral inhibition by Mx2

Award Number: F32AI116263

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/13/2017

PERIOD OF PERFORMANCE END DATE: 02/12/2018

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