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The role of alcohol-associated microbiota membrane vesicles in mucosal immunity

Award Number: F32AA031180
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 04/28/2023
PERIOD OF PERFORMANCE END DATE: 04/27/2026

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The role of alcohol-associated microbiota membrane vesicles in mucosal immunity - A significant portion of the global burden of AUD (Alcohol use disorder) derives from an increased risk and susceptibility to diseases including infection, cirrhosis, and cancer. These diseases are influenced by the composition of the intestinal microbiota, which is altered by alcohol use. Though it has been accepted that change to the microbiota contributes to disease establishment and progression in AUD, our understanding of the mechanisms by which this occurs is inadequate. These mechanisms likely involve a variety of microbiota- derived products (membrane vesicles, excreted chemicals, cellular components, LPS, etc.). The preliminary data addressed herein support the proposition that microbiota-derived membrane vesicles (MVs) are an important driver of alcohol-driven tissue injury. To address this possibility, this proposal will examine the effects of alcohol on the composition and frequency of microbiota derived MVs. This proposal will also evaluate the effects of alcohol-associated MVs on promoting tissue injury and mucosal infection. Our preliminary data demonstrate that alcohol alters the composition of MVs generated by the gut microbiota, and that isolated alcohol-associated MVs increase susceptibility to respiratory infection, independent of alcohol use, suggesting that MVs influence mucosal host defense. We hypothesize that MVs from an alcohol-associated microbiota will have increased inflammatory properties and increase susceptibility to mucosal infections via epithelial inflammation and barrier dysfunction. Understanding the alterations to bacterial MVs following alcohol exposure may give new insight into disease pathogenesis, which may inspire future therapies centered on modulating MVs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $81,724 )
2025	2025	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	4215 EMILE ST	OMAHA	NE	68105	DOUGLAS	USA	Alcohol Research Programs	000	3	5/14/2025	NON-COMPETING CONTINUATION	$80,392
2025	2025	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	4215 EMILE ST	OMAHA	NE	68105	DOUGLAS	USA	Alcohol Research Programs	001	3	6/6/2025	NON-COMPETING CONTINUATION	$1,332
														Subtotal = $81,724

Issue Date FY: 2024 ( Subtotal = $78,256 )
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Alcohol Research Programs	000	2	3/26/2024	NON-COMPETING CONTINUATION	$73,292
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Alcohol Research Programs	001	2	5/1/2024	NON-COMPETING CONTINUATION	$4,964
														Subtotal = $78,256

Issue Date FY: 2023 ( Subtotal = $71,000 )
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Alcohol Research Programs	001	1	4/28/2023	NEW	$0
2023	2023	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Alcohol Research Programs	000	1	4/28/2023	NEW	$71,000
														Subtotal = $71,000

Grand Total All Awards = $230,980

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The role of alcohol-associated microbiota membrane vesicles in mucosal immunity

Award Number: F32AA031180

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 04/28/2023

PERIOD OF PERFORMANCE END DATE: 04/27/2026

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