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Metabolic control of cue reactivity during alcohol withdrawal

Award Number: F32AA030475
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/01/2022
PERIOD OF PERFORMANCE END DATE: 04/30/2025

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Metabolic control of cue reactivity during alcohol withdrawal - PROJECT SUMMARY Alcohol use disorder (AUD) is one of the most prevalent psychiatric disorders in the United States. Chronic alcohol consumption in individuals with AUD is associated with lowered glucose metabolism and increased acetate metabolism in the brain. Following abrupt cessation of alcohol consumption, sudden decreases in acetate may cause the brain to become “energy-deprived”, which could induce heightened craving and symptoms of withdrawal. The main goal of this proposal is to test the hypothesis that energy deprivation during withdrawal contributes to alcohol craving by influencing reward-encoding neural circuitry. Analyses for Specific Aim 1 will focus on defining the impact of altered brain metabolism in the dorsal anterior cingulate cortex (dACC) on its connectivity with the ventral striatum (VS) and on specifying the role of connectivity between the dACC and VS in facilitating whole-brain transitions to alcohol cue-induced neural activity states. Analyses for Specific Aim 2 will seek to define the relationship between metabolic function in the dACC, its role in driving whole-brain dynamics, and alcohol craving. Completion of this proposal will provide a framework for predicting the impact of metabolic interventions on brain state and craving, which will aid the development of therapeutic approaches for AUD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $37,515 )
2025	2025	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Alcohol Research Programs	000	3	12/18/2024	NON-COMPETING CONTINUATION	$37,515
														Subtotal = $37,515

Issue Date FY: 2024 ( Subtotal = $78,784 )
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Alcohol Research Programs	000	2	11/1/2023	NON-COMPETING CONTINUATION	$74,000
2024	2024	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Alcohol Research Programs	001	2	5/1/2024	NON-COMPETING CONTINUATION	$4,784
														Subtotal = $78,784

Issue Date FY: 2022 ( Subtotal = $71,674 )
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Alcohol Research Programs	001	1	9/1/2022	NEW	$0
2022	2022	TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE	3451 WALNUT ST STE 440A	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Alcohol Research Programs	000	1	9/1/2022	NEW	$71,674
														Subtotal = $71,674

Grand Total All Awards = $187,973

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Metabolic control of cue reactivity during alcohol withdrawal

Award Number: F32AA030475

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/01/2022

PERIOD OF PERFORMANCE END DATE: 04/30/2025

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