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Determining a Central Locus for Temperature Modulation of Touch Sensitivity

Award Number: F31NS135914
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/08/2024
PERIOD OF PERFORMANCE END DATE: 02/07/2027

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Determining a Central Locus for Temperature Modulation of Touch Sensitivity - Project Summary: The interactions between touch and temperature perception are essential for the human experience & behavior, object recognition, thermoregulation, and avoidance of harmful stimuli. Despite their importance, these modalities are mostly studied in isolation. Previous studies have shown that innocuous and noxious skin temperature alters the perception of tactile stimulation, and evidence suggests that thermo-tactile modulation may occur both peripherally and centrally. However, it remains unclear whether innocuous and noxious thermo-tactile interactions occur centrally or solely in the periphery. Additionally, the neural substrates that reflect thermo-tactile interactions remain unknown in humans and non-human primates and it remains unknown whether Primary Somatosensory (S1) neurons encode cutaneous thermal information during these interactions. I hypothesize that innocuous and noxious thermo-tactile interactions have a central locus of interaction and further hypothesize that S1 neurons may reflect warm or cool temperatures via modulation of their neural firing rates to vibratory stimuli. To address these gaps, I propose three specific aims. First, Aim 1 will determine if illusory thermal cues modulate vibrotactile perception, where the vibration detection thresholds of human subjects under veridical and illusory thermal cues (thermal referral illusion) will be compared. Second, Aim 2 will determine if illusory thermal pain modulates vibrotactile perception, where the vibration detection thresholds of human subjects under veridical and illusory thermal pain (thermal grill illusion) conditions will be compared. Third, Aim 3 will determine if S1 neural responses to vibrations are modulated by skin temperature, where the neural firing rates of well-isolated single- or populations of S1 neurons in NHPs will be recorded while vibration cues are delivered to the finger pads under different thermal conditions. The findings of this study will provide the first evidence of a central locus of innocuous and noxious thermo-tactile modulation in humans and improve our understanding of the neural substrates that reflect thermo-tactile interactions. Ultimately, this study has the potential to inform the development of therapies for patients with impaired thermo-tactile perception.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $53,114 )
2026	2026	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	4/15/2026	NON-COMPETING CONTINUATION	$576
2026	2026	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	1/23/2026	NON-COMPETING CONTINUATION	$52,538
														Subtotal = $53,114

Issue Date FY: 2025 ( Subtotal = $52,538 )
2025	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	1/29/2025	NON-COMPETING CONTINUATION	$51,974
2025	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	8/20/2025	NON-COMPETING CONTINUATION	$564
														Subtotal = $52,538

Issue Date FY: 2024 ( Subtotal = $51,974 )
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/8/2024	NEW	$50,194
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	1/8/2024	NEW	$0
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	1	8/15/2024	NEW	$1,780
														Subtotal = $51,974

Grand Total All Awards = $157,626

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Determining a Central Locus for Temperature Modulation of Touch Sensitivity

Award Number: F31NS135914

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/08/2024

PERIOD OF PERFORMANCE END DATE: 02/07/2027

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