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Oligodendrocyte Lineage Cell Mechanisms of Axon Selection for Myelination

Award Number: F31NS125915
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/04/2022
PERIOD OF PERFORMANCE END DATE: 11/03/2024

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Oligodendrocyte Lineage Cell Mechanisms of Axon Selection for Myelination - PROJECT SUMMARY Oligodendrocytes are the resident myelinating cell type of the central nervous system. Recent work indicates that different classes of neurons have differing patterns and distribution of myelin along their axons. Yet only recently has the identity of the axons been considered with respect to myelination. Thus, the mechanisms of axon signaling and selection for myelination remain largely unknown. Our lab and others have shown that neuronal activity increases myelination and synaptic vesicle release occurs along axons underneath myelin sheaths, suggesting oligodendrocytes may need to be able to receive and interpret neurotransmitter signaling. A single oligodendrocyte can myelinate up to 40 distinct axons, posing a unique situation where an individual cell may need to adapt to signaling from many different neurons. How might this be achieved? Oligodendrocytes express many canonical post-synaptic factors, ostensibly to aid in signaling between the axon and myelin sheath, but the role these proteins play in myelinating cells is largely unknown. Using a zebrafish model, this proposal will utilize genetic approaches and in vivo imaging to address two fundamental concepts: is there a pattern to the expression and/or localization of these post-synaptic factors in oligodendrocytes and does this correspond to wrapped axonal identity; and what function do they serve in the process of myelination. This will be achieved in two aims: Aim 1 tests what post-synaptic factors are expressed, where these post-synaptic proteins localize, and when are they important; and Aim 2 tests how these proteins function to facilitate myelination, and if there is a correlation between axon identity and localization and function of post-synaptic proteins in myelinating oligodendrocytes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$7,869 )
2025	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	9/26/2025	NON-COMPETING CONTINUATION	-$7,869
														Subtotal = -$7,869

Issue Date FY: 2024 ( Subtotal = $35,548 )
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	6/17/2024	NON-COMPETING CONTINUATION	$1,100
2024	2024	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	3	12/8/2023	NON-COMPETING CONTINUATION	$34,448
														Subtotal = $35,548

Issue Date FY: 2023 ( Subtotal = $38,972 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	12/20/2022	NON-COMPETING CONTINUATION	$38,030
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	2	2/14/2023	NON-COMPETING CONTINUATION	$942
														Subtotal = $38,972

Issue Date FY: 2022 ( Subtotal = $38,030 )
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	11/8/2021	NEW	$0
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	1	5/31/2022	NEW	$716
2022	2022	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	11/8/2021	NEW	$37,314
														Subtotal = $38,030

Grand Total All Awards = $104,681

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Oligodendrocyte Lineage Cell Mechanisms of Axon Selection for Myelination

Award Number: F31NS125915

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/04/2022

PERIOD OF PERFORMANCE END DATE: 11/03/2024

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