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The PDGF alpha neural progenitor cells of the subventricular zone contributes to

Award Number: F31NS076269
ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/13/2012
PERIOD OF PERFORMANCE END DATE: 08/12/2014

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The PDGF alpha neural progenitor cells of the subventricular zone contributes to - DESCRIPTION (provided by applicant): Glioblastoma (GBM) represents the majority of diagnosed brain tumors with a high rate of mortality. GBM is a heterogeneous glial tumor found in the adult cerebral cortex. Due to the heterogeneity within the tumor and from patient to patient, treatment is extremely challenging. Many clinicians and researchers believe that targeting the tumor "cell of origin" will be key to providing better outcomes for patients. Whether GBMs arise from a transformed stem cell or a more differentiated cell that has been transformed is hotly debated. Platelet derived growth factor (PDGF) is a molecule that is over expressed and drives tumor growth in the Proneural subclass of GBMs. I aim to isolate the PDGFR¿+ cells that reside in the subventricular zone (SVZ) of transgenic mice by flow cytometry and FACs. I will sort out distinct populations based on an array of cell surface markers identified by previous experiments, CD133/LeX/NG2/PDGFR¿/A2B5/EGFR. The cells will be transformed in culture by a deletion of the p53 tumor suppressor and exposure to constitutively expressed PDGF. I will evaluate the tumorigenicity of the different populations of cells along with analyzing the histological and antigenic profile of the different tumors. We hypothesize that there are multiple PDGFR¿+ "cells of origin" that can contribute to GBM tumor formation. We also expect variations in tumor susceptibility and the resulting tumors based on the phenotype of the tumor cell of origin. This research will help to answer questions in the cancer biology field that underestimate progenitor cells capacity to form malignant brain tumors. This research is vital to the advancement and understanding of the cancer stem cell hypothesis that is leading cancer research and thought to be associated with untreatable cancers, like GBM. Ultimately if we can identify and characterize the "cell of origin" then we will be better equipped to make drugs that will specifically target the cell that continues to give rise to the tumor, whether it is a stem cel or a progenitor cell.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$49,498 )
2017	2014	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	185 S ORANGE AVE	NEWARK	NJ	07103	ESSEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	4	9/14/2017	NON-COMPETING CONTINUATION	-$29,458
2017	2013	RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY	185 S ORANGE AVE	NEWARK	NJ	07103	ESSEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	9/14/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$20,040
														Subtotal = -$49,498

Issue Date FY: 2014 ( Subtotal = $71,690 )
2014	2014	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	002	4	3/18/2014	NON-COMPETING CONTINUATION	$29,458
2014	2013	Rutgers, The State Univ Biomedical & Health Sciences	65 Davidson Road	Piscataway	NJ	08854	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	1/24/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$48,448
2014	2012	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	POST OFFICE BOX 2100	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	1/24/2014	NEW	-$6,216
														Subtotal = $71,690

Issue Date FY: 2013 ( Subtotal = $90,680 )
2013	2013	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	POST OFFICE BOX 2100	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	2	3/29/2013	NON-COMPETING CONTINUATION	$42,232
2013	2013	Rutgers, The State Univ Biomedical & HEALTH Sciences	65 Davidson Road	Piscataway	NJ	08554		USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	3	1/24/2014	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$48,448
														Subtotal = $90,680

Issue Date FY: 2012 ( Subtotal = $42,232 )
2012	2012	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	POST OFFICE BOX 2100	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	001	1	2/13/2012	NEW	$42,232
2012	2012	UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY	POST OFFICE BOX 2100	NEW BRUNSWICK	NJ	08903	MIDDLESEX	USA	Extramural Research Programs in the Neurosciences and Neurological Disorders	000	1	2/13/2012	NEW	$0
														Subtotal = $42,232

Grand Total All Awards = $155,104

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The PDGF alpha neural progenitor cells of the subventricular zone contributes to

Award Number: F31NS076269

ORGANIZATION: NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/13/2012

PERIOD OF PERFORMANCE END DATE: 08/12/2014

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