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Migraine, Depressive Symptoms, and Maternal Quality of Life in the Postpartum Period: The Role of Comorbidity, Disengagement, and Social and Economic Disadvantage

Award Number: F31NR019712
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Migraine, Depressive Symptoms, and Maternal Quality of Life in the Postpartum Period: The Role of Comorbidity, Disengagement, and Social and Economic Disadvantage - Migraine affects one in three women of childbearing age in the United States (U.S.). Women with migraine have up to a five-fold increased risk for comorbid depression. The postpartum period is an especially challenging time for women with migraine, as rapid hormonal shifts, fatigue, exhaustion, and increased external stressors are known triggers for both migraine and postpartum depressive symptoms. If women’s migraine self-management style (MSMS) primarily involves disengagement (i.e. social withdrawal, avoidance, wishful thinking), the implications for developing depressive symptoms and synergistically worsening symptoms across conditions may be more significant. These risks may be exponentially more harmful to women who have lower levels of personal resources (PR) that have been shown to facilitate effective chronic disease self-management in other non-migraine disease states, as they experience the greatest burden from migraine and postpartum depressive symptoms. A syndemic is characterized by the (1) higher prevalence of these co-occurring disorders, and (2) synergism that exists across symptoms and self-management strategies of one condition (migraine) that facilitates developing a comorbid condition (depression) are influenced by (3) social contextual factors (social and/or economic disadvantage in the face of postpartum demands). Despite the high prevalence of these disorders individually, the increased risk for comorbid migraine-depressive symptoms in the postpartum period, and the potential impact on women and their families, there is a paucity of research in this area. The proposed study will use a syndemics framework to understand the relationships, mechanisms, and interactions among migraine and depressive symptoms, disengagement, and level of PR over the first 3 months postpartum. This will be accomplished by the following: Aim 1: Examine the relationships among (a) migraine symptom severity, (b) depressive symptom severity, (c) level of disengagement as a migraine self-management style, and (d) level of personal resources, over time. Aim 1a: Test the extent to which disengagement mediates the relationship between migraine symptom severity and depressive symptom severity. Aim 1b: Determine whether the level of personal resources moderates the extent to which disengagement mediates the migraine-depressive symptom relationship. Aim 2: Compare maternal quality of life among women who develop the syndemic factor (comorbid migraine and moderate-to-severe postpartum depressive symptoms) and women who do not. The applicant has outlined a comprehensive training plan to be completed under this award. Outcomes of the study and training plan will provide the applicant with skills and data to pursue a career development award on prevention-oriented interventions targeting syndemic conditions that may be useful in disrupting the development of postpartum depressive symptomatology among women with migraine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $9,233 )
2026	2026	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	000	3	12/22/2025	NON-COMPETING CONTINUATION	$9,137
2026	2026	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	001	3	3/30/2026	NON-COMPETING CONTINUATION	$96
														Subtotal = $9,233

Issue Date FY: 2025 ( Subtotal = $41,432 )
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	002	2	6/9/2025	NON-COMPETING CONTINUATION	$0
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	001	2	6/5/2025	NON-COMPETING CONTINUATION	$564
2025	2025	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	000	2	11/27/2024	NON-COMPETING CONTINUATION	$40,868
														Subtotal = $41,432

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	001	1	8/14/2024	NEW	$0
2024	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	000	1	11/21/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	000	1	5/11/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $38,190 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	002	1	9/10/2021	NEW	$0
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	001	1	6/28/2021	NEW	$0
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	003	1	9/10/2021	NEW	$0
2021	2021	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Nursing Research	000	1	6/28/2021	NEW	$38,190
														Subtotal = $38,190

Grand Total All Awards = $88,855

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Migraine, Depressive Symptoms, and Maternal Quality of Life in the Postpartum Period: The Role of Comorbidity, Disengagement, and Social and Economic Disadvantage

Award Number: F31NR019712

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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