Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Frontocortical representations of amygdala-mediated learning under uncertainty

Award Number: F31MH135698
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/01/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2025

Group Awards By:

View Award Description

Frontocortical representations of amygdala-mediated learning under uncertainty - Project Abstract Learning is one of the essential building blocks of cognition. Individuals with mental health conditions, such as bipolar disorders and schizophrenia, often show symptoms related to learning. A great deal of evidence exists indicating that the orbitofrontal cortex (OFC) and anterior cingulate cortex (ACC) are both heavily involved in flexible learning under uncertainty, with the basolateral amygdala (BLA) sending robust bidirectional connections to both cortical structures. I hypothesize that BLA provides OFC and ACC with dissociable signals that delineate a difference in the expected reward and what was received, vital information for adaptive learning. In Aim 1, rats will be tested on a novel, dynamic, restless bandit task for flexible learning under different probabilistic schedules where the reward contingencies switch within the session. While rats perform this task in some sessions, we will chemogenetically inhibit BLA. A subset of these rats will also express GCaMP6f in OFC and GRIN lenses directly in this region so that we can use miniscopes to record calcium traces while the freely-moving rat learns. In parallel Aim 2, rats learning on the same task will instead have BLA on- or off-line while I record calcium traces in ACC. These approaches will allow us to study how the uncertainty representations in OFC and ACC differentially depend on BLA input. My central hypothesis is that OFC and ACC use BLA-supplied information differently: OFC receives information from BLA that is needed to detect first reversals and setting future adjustments, whereas ACC uses information from BLA to approximate changes in probabilities over time.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2027 ( Subtotal = -$12,336 )
2027	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	2	10/27/2026	NON-COMPETING CONTINUATION	-$12,336
														Subtotal = -$12,336

Issue Date FY: 2025 ( Subtotal = $41,872 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	2	1/25/2025	NON-COMPETING CONTINUATION	$41,308
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	001	2	9/8/2025	NON-COMPETING CONTINUATION	$564
														Subtotal = $41,872

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	1	11/2/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $40,028 )
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	001	1	9/12/2023	NEW	$0
2023	2023	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Mental Health Research Grants	000	1	9/12/2023	NEW	$40,028
														Subtotal = $40,028

Grand Total All Awards = $69,564

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Frontocortical representations of amygdala-mediated learning under uncertainty

Award Number: F31MH135698

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/01/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2025

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer