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Hydrogel Microparticles for High-Throughput Platelet Profiling in Heavy Menstrual Bleeding

Award Number: F31HL186582
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/22/2026
PERIOD OF PERFORMANCE END DATE: 12/21/2027

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Hydrogel Microparticles for High-Throughput Platelet Profiling in Heavy Menstrual Bleeding - Project Summary Heavy menstrual bleeding (HMB) is a common clinical concern among adolescent girls and women, yet many receive a diagnosis of bleeding of unknown cause (BUG) despite extensive clinical testing. This diagnosis of exclusion reflects a critical gap in platelet function diagnostics: current assays fail to detect the platelet dysfunctions that may underlie bleeding symptoms. The standard platelet function assay, light transmission aggregometry, has changed little since its introduction in 1962 and does not account for recent insights into platelet mechanobiology or force-dependent adhesion. There is an urgent need for sensitive, physiologically relevant diagnostics to detect platelet dysfunction in understudied populations such as women with HMB. The central hypothesis of this project is that platelet adhesion and aggregation responses differ between women with HMB and healthy individuals. A hydrogel microparticle platform has been developed that mimics physiologic hemodynamic conditions and supports high-throughput assessment of platelet adhesion and aggregation to key ligands under flow. This project will use this platform to quantify platelet responses in those with HMB and compare them to normative ranges. Aim 1 will define sex-specific normative ranges of platelet adhesion and aggregation on hydrogel microparticles in healthy individuals and compare these to existing clinical platelet function assays. Pharmacologic perturbation with antiplatelet agents will be used to characterize assay sensitivity to specific activation pathways. Aim 2 will assess platelet function in women with HMB who have received a diagnosis of BUG. Platelet adhesion and aggregation profiles will be compared to those of healthy controls and women with known bleeding disorders such as von Willebrand disease. Outputs will also be correlated with bleeding scores and treatment histories to identify potential bleeding subtypes. Completion of this project will yield a validated, flow-based platelet function assay capable of detecting dysfunction not captured by current diagnostics. By addressing a major gap in bleeding disorder assessment, this work has the potential to improve diagnostic accuracy and clinical management for individuals, especially adolescent girls and young women.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $37,674 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Blood Diseases and Resources Research	000	1	6/23/2026	NEW	$37,674
														Subtotal = $37,674

Grand Total All Awards = $37,674

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Hydrogel Microparticles for High-Throughput Platelet Profiling in Heavy Menstrual Bleeding

Award Number: F31HL186582

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/22/2026

PERIOD OF PERFORMANCE END DATE: 12/21/2027

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