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Improving Postpartum Hemorrhage Care in Resource-Constrained Settings: Risk Factors and Optimized Care

Award Number: F31HL184922
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/25/2026
PERIOD OF PERFORMANCE END DATE: 12/24/2027

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Improving Postpartum Hemorrhage Care in Resource-Constrained Settings: Risk Factors and Optimized Care - Postpartum hemorrhage (PPH) is one of the leading causes of maternal death worldwide and remains a major cause of preventable maternal morbidity and mortality in the United States. The proposed study will characterize PPH including population characteristics, treatment outcomes, and management practices with the primary purpose of generating actionable insights into PPH management that directly inform clinical care and quality improvement in both low-resource and U.S. settings. The study is set in N’Djamena, Chad, a country with one of the highest maternal mortality ratios globally. Conducting this research in a high-burden setting enables efficient identification of high-risk populations, evaluation of significant predictors, and detection of gaps in care delivery that are more difficult to observe in lower-incidence settings such as the United States. Findings will be used to inform evidence-based strategies for improving risk stratification, optimizing treatment processes, and strengthening adherence to obstetric safety protocols, priorities directly relevant to U.S. maternal health systems. Aim 1 will characterize postpartum hemorrhage. We will use descriptive analyses of causes, characteristics, and treatments among women experiencing PPH. We will apply traditional statistical and machine learning approaches to identify predictive risk factors for hemorrhage, generating models that can inform risk assessment strategies applicable to U.S. clinical care. Aim 2 will assess treatment outcomes and risk factors for PPH. Using hierarchical clustering, nested logistic regression, and latent class analysis (LCA), we will classify treatment pathways and model treatment effectiveness. These analyses will identify distinct patient subgroups and inform stratified management approaches relevant to improving outcomes in heterogeneous U.S. obstetric populations. Aim 3 will describe PPH management processes and decisionmaking. Through in-depth interviews with care providers, we will characterize barriers and facilitators to adherence to obstetric safety bundles using the COM-B framework. Findings will inform implementation strategies to improve adherence to evidence-based practices, an ongoing challenge in U.S. hospital systems. While focused on pregnancy in Chad, with one of the highest maternal and infant mortality rates in the world, the lessons learned will be applicable directly to the United States, given the vastness of our rural regions (the American south, west, and Alaska, most notably). As the F31 trainee, I will apply lessons learned to our nation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $49,282 )
2026	2026	GEORGE WASHINGTON UNIVERSITY (THE)	1918 F ST NW	WASHINGTON	DC	20052	DISTRICT OF COLUMBIA	USA	Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders	000	1	7/1/2026	NEW	$49,282
														Subtotal = $49,282

Grand Total All Awards = $49,282

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Improving Postpartum Hemorrhage Care in Resource-Constrained Settings: Risk Factors and Optimized Care

Award Number: F31HL184922

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/25/2026

PERIOD OF PERFORMANCE END DATE: 12/24/2027

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