Tuesday, July 1, 2025 7/1/2025

TOPOGENESIS OF POSTSYNAPTIC MEMBRANES.

Award Number: F31GM078814
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 04/01/2007
PERIOD OF PERFORMANCE END DATE: 03/31/2009

Group Awards By:

View Award Description

TOPOGENESIS OF POSTSYNAPTIC MEMBRANES. - DESCRIPTION (provided by applicant): The objective of this proposal is to identify the molecular mechanisms responsible for neuron-induced clustering of muscle nicotinic acetylcholine receptors (AChRs) in postsynaptic membranes during formation of neuromuscular junctions. The focus is on the signaling elicited by the extracellular matrix components agrin and laminin and the role of a specific family of regulatory proteins - the Rho GTPases - as crucial mediators of AChR clustering. This project stems from recent findings that the coupling of both agrin and laminin signaling to AChR clustering is critically dependent on the activities of three Rho GTPases - Cdc42, Rac, and Rho - that couple extracellular signaling to localized changes in peripheral actin-based cytoarchitecture. The molecular mechanisms by which agrin/laminin elicit RhoGTPase activation as well as the means by which this activation is transduced into localized AChR clustering are not understood at present. The proposed studies will utilize cultured muscle cell lines, transfection techniques, biochemical assays and fluorescence imaging to analyze the mechanistic basis for the induction of AChR redistribution into high density clusters on the muscle cell surface in response to these extracellular cues.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $27,522 )
2008	2008	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Biomedical Research and Research Training	000	2	3/24/2008	NON-COMPETING CONTINUATION	$27,522
														Subtotal = $27,522

Issue Date FY: 2007 ( Subtotal = $27,522 )
2007	2007	RESEARCH FOUNDATION OF STATE UNIV OF NEW YORK (SUNY)	PO BOX 9	ALBANY	NY	12201	ALBANY	USA	Biomedical Research and Research Training	000	1	2/21/2007	NEW	$27,522
														Subtotal = $27,522

Grand Total All Awards = $55,044

Top

All Categories

About

Search

Reports

Data Submission

Award Information

TOPOGENESIS OF POSTSYNAPTIC MEMBRANES.

Award Number: F31GM078814

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 04/01/2007

PERIOD OF PERFORMANCE END DATE: 03/31/2009

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer