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PREDOCTORAL FELLOWSHIP FOR STUDENTS WITH DISABILITIES

Award Number: F31GM067560
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: PLANNING
PERIOD OF PERFORMANCE START DATE: 08/22/2003
PERIOD OF PERFORMANCE END DATE: 11/21/2006

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PREDOCTORAL FELLOWSHIP FOR STUDENTS WITH DISABILITIES - DESCRIPTION (provided by applicant): Scientists have used computational simulations to observe geometry optimization of molecules like proteins and to calculate the free energy differences between two molecules. Most simulations encounter large energy barriers that prevent the observation of a folded protein accurately or that prevent the calculation of absolute free energies. With methods developed in the lab of Dr. Ralph A. Wheeler, I will predict the correct folded structure of a protein and will calculate not only the relative free energy differences between molecules, but the absolute free energy of a molecule. First, I will test the geometry optimization method on dialanine, divaline, an a-helical polypeptide and a b-sheet polypeptide. I will extend the tests on prion proteins observing the folding of the mostly alpha-helical protein to the beta-sheet dominant protein. I will test the free energy calculation method with small organic molecules, dipeptides, and helix-forming and sheet-forming proteins. The tests will be extended to point mutations of the prion proteins calculating the propensities of the protein. Finally, calculations will be done to find the binding free energy differences between molecules bound to the prion protein. Through these simulations, drugs could be designed to combat the prion disease. Such possibilities include the stabilization of the a-helical form or the prevention of aggregation after the b-sheets are formed.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $7,012 )
2006	2006	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	1000 ASP AVENUE	NORMAN	OK	73109		USA	Biomedical Research and Research Training	000	4	7/25/2006	NON-COMPETING CONTINUATION	$7,012
														Subtotal = $7,012

Issue Date FY: 2005 ( Subtotal = $25,299 )
2005	2005	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	1000 ASP AVENUE	NORMAN	OK	73109		USA	Biomedical Research and Research Training	000	3	7/18/2005	NON-COMPETING CONTINUATION	$25,299
														Subtotal = $25,299

Issue Date FY: 2004 ( Subtotal = $25,299 )
2004	2004	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	555 CONSTITUTION ST., STE. 237	NORMAN	OK	73072	CLEVELAND	USA	Biomedical Research and Research Training	000	2	7/15/2004	NON-COMPETING CONTINUATION	$25,299
														Subtotal = $25,299

Issue Date FY: 2003 ( Subtotal = $24,495 )
2003	2003	UNIVERSITY OF OKLAHOMA NORMAN CAMPUS	555 CONSTITUTION ST., STE. 237	NORMAN	OK	73072	CLEVELAND	USA	Minority Access to Research Careers	000	1	8/22/2003	NEW	$24,495
														Subtotal = $24,495

Grand Total All Awards = $82,105

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PREDOCTORAL FELLOWSHIP FOR STUDENTS WITH DISABILITIES

Award Number: F31GM067560

ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: PLANNING

PERIOD OF PERFORMANCE START DATE: 08/22/2003

PERIOD OF PERFORMANCE END DATE: 11/21/2006

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