Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Structure and function of parabigeminal projections to the mouse dorsal lateral geniculate nucleus

Award Number: F31EY038568
ORGANIZATION: NATIONAL EYE INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 05/05/2026
PERIOD OF PERFORMANCE END DATE: 05/04/2029

Group Awards By:

View Award Description

Structure and function of parabigeminal projections to the mouse dorsal lateral geniculate nucleus - Project Summary/Abstract Within the dorsal lateral geniculate nucleus (dLGN), parallel pathways are formed via segregated circuits that parse different aspects of the visual scene. Comparative studies show that across mammals, inputs from the superior colliculus (SC) and its satellite, the parabigeminal nucleus (PBG), innervate restricted regions of the dLGN, namely the dorsolateral shell in rodent species. The dLGN shell also receives input from retinal ganglion cells (RGCs) that exhibit direction-selective (DS) responses and are convergent with inputs from the SC to innervate single dLGN shell neurons that project to layer 1 of the primary visual cortex. While classic dLGN studies define the region by the relay of information from retina to visual cortex (V1), the contribution of DS nonretinal inputs (such as from SC and PBG) to dLGN function is less understood. More specifically, little is known regarding the PBG neurons that project to the dLGN, the synaptic integration of PBG inputs within the dLGN, or how they impact the responses of neurons in the dLGN shell. I propose to address these gaps in knowledge using a variety of anatomical and functional methodologies for a detailed examination of circuits linking PBG and dLGN (PBG-dLGN). Aim 1 experiments will utilize anterograde and retrograde viral tracers to determine whether PBG-dLGN neurons branch to innervate multiple targets and in vitro electrophysiology and optogenetics to ascertain the connectivity between DS SC neurons (narrow-field vertical cells) and PBG-dLGN neurons. Aim 2 experiments will utilize electron microscopy, in vitro electrophysiology and optogenetics to determine whether PBG, SC and RGC terminals converge to innervate single cells in the shell of the dLGN. Lastly, Aim 3 experiments employ in vivo electrophysiology and optogenetic techniques to determine how the PBG alters dLGN visual response properties. This combination of approaches will address fundamental questions regarding the circuity of the PBG and dLGN while providing the applicant with broad- based training in neuroscience techniques.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $40,174 )
2026	2026	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Vision Research	000	1	5/5/2026	NEW	$40,174
2026	2026	UNIVERSITY OF LOUISVILLE	2301 S 3RD ST	LOUISVILLE	KY	40208	JEFFERSON	USA	Vision Research	001	1	5/5/2026	NEW	$0
														Subtotal = $40,174

Grand Total All Awards = $40,174

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Structure and function of parabigeminal projections to the mouse dorsal lateral geniculate nucleus

Award Number: F31EY038568

ORGANIZATION: NATIONAL EYE INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 05/05/2026

PERIOD OF PERFORMANCE END DATE: 05/04/2029

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer