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Exposure to metabolism disrupting chemicals: implications for maternal health in pregnancy

Award Number: F31ES037232
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/16/2025
PERIOD OF PERFORMANCE END DATE: 02/15/2027

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Exposure to metabolism disrupting chemicals: implications for maternal health in pregnancy - Support from this award will provide Maria Cinzori with comprehensive training in environmental epidemiology and clinically-relevant perinatal health research, while providing additional guidance for conducting research using a large national cohort (the Environmental influences on Child Health Outcomes (ECHO) consortium) and applying causal inference-based statistical approaches under the supervision of an exceptional mentoring team with expertise in environmental epidemiology, conducting perinatal health research (including in clinical settings), and confronting the challenges and rewards of working with a large, harmonized dataset. Overall, the proposed research will offer insights into associations between metabolism disrupting chemical (MDC) exposures and maternal metabolic disorders in pregnancy. Pregnant women are exposed to numerous non-persistent (e.g., phthalates, phenols) MDCs through food packaging, personal care products, and household cleaning items. Some limited studies suggest that certain single MDCs are linked to gestational diabetes and hypertensive disorders of pregnancy – conditions that may increase maternal and child risk of developing type II diabetes or obesity. Therefore, MDCs may be potential modifiable risk factors that can be targeted to prevent gestational and cardiovascular complications. However, prior studies addressing this issue have been limited, focusing primarily on non-clinical metabolic outcomes and single chemical classes in homogenous populations. Specific Aim 1 of the current study will address this critical gap by evaluating associations of maternal exposure to many classes of MDCs with gestational diabetes and hypertensive disorders of pregnancy. Completion of the research in Specific Aim 1 will leverage data from ECHO, a large national cohort, to provide vital information on how MDCs impact gestational metabolic health. Despite efforts to ban harmful chemicals, pregnant women are ubiquitously exposed to emerging chemicals of concern via continuous introduction of unregulated replacements. Although prior intervention studies evaluating phenols and phthalates suggest that there are plausible individual-level approaches for reducing exposure to chemicals, it is time-consuming to test whether implementing large-scale intervention is effective at improving health outcomes. To address these shortcomings, Specific Aim 2 will apply novel causal inference-based statistical methods to evaluate how a hypothetical intervention to decrease exposure to chemicals of concern would impact risk of developing gestational diabetes or hypertensive disorders of pregnancy in pregnant women enrolled in ECHO. Furthermore, it is critical to identify sources of emerging MDCs to inform future interventions, and therefore an exploratory aim will extensively review the literature to identify targetable sources of novel and emerging MDCs with the goal of informing sustainable interventions. The research accomplished in Specific Aim 2 will provide valuable information about whether reducing MDC exposure can lower the incidence of gestational diabetes and hypertensive disorders of pregnancy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $17,057 )
2026	2026	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 360	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	2	7/14/2026	NON-COMPETING CONTINUATION	$17,057
														Subtotal = $17,057

Issue Date FY: 2025 ( Subtotal = $42,399 )
2025	2025	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	002	1	9/26/2025	NEW	$0
2025	2025	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	001	1	9/26/2025	NEW	$0
2025	2025	MICHIGAN STATE UNIVERSITY	426 AUDITORIUM RD RM 2	EAST LANSING	MI	48824	INGHAM	USA	Environmental Health	000	1	8/4/2025	NEW	$42,399
														Subtotal = $42,399

Grand Total All Awards = $59,456

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Exposure to metabolism disrupting chemicals: implications for maternal health in pregnancy

Award Number: F31ES037232

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/16/2025

PERIOD OF PERFORMANCE END DATE: 02/15/2027

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