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Consequences of Maternal Vaping on Cerebrovascular Health in Offspring

Award Number: F31ES034646
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 03/01/2023
PERIOD OF PERFORMANCE END DATE: 05/01/2024

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Consequences of Maternal Vaping on Cerebrovascular Health in Offspring - Project Summary/Abstract Electronic cigarettes (E-cigs) are promoted as an alternative to smoking during pregnancy, however the immediate and long-term effects are still unknown. Current estimates are that 5-16% of pregnant women will use e-cigs with the expectation that are either ‘reduced’ or ‘no’ risk to offspring health. Yet, inhalation exposures during pregnancy are of significant concern, because: 1) the developing fetus is at a vulnerable period, and 2) even ‘low-levels’ of smoking during pregnancy are known to have measurable vascular health risk to offspring. Thus, there is a critical need for preclinical studies to examine vascular related outcomes, particularly in the context of exposure during pregnancy. We have previously established the maternal vaping during pregnancy significantly impairs cerebral vascular function in offspring (even through adulthood). The goal of this proposal is to evaluate the direct effect of vape exposure on offspring born with prior history of in utero exposure due to maternal vaping, and secondly to determine whether full-term vs limited trimester exposure produces differences in cerebral vascular structure and function in offspring in adolescent and adult life. Based on our preliminary data, our overall hypothesis is that e- cig usage during pregnancy (irrespective of nicotine) creates a hostile gestational environment that leads to reduced cerebral vascularity and blunted vascular responses in offspring later in life. Aim 1 will combine direct e-cig exposure in adolescent- and adult-aged offspring that already have blunted cerebral vascular reactivity secondary to in utero exposure from maternal vaping. Aim 2 will use different exposure patterns of maternal vaping during pregnancy (full-term vs individual trimester exposures) to determine if there is critical exposure window that (more greatly) influences cerebral vascular structure and function in offspring. The proposed studies will identify consequences of maternal vaping combined with secondary direct exposure to offspring later in life; and identify what time frame during pregnancy that vaping might have the greatest influence on cerebral vascular health on offspring. We anticipate our data will provide toxicological and clinical evidence to inform clinicians and consumers on consequences of vaping during pregnancy, as well as information for regulatory agencies when establishing public policy, guidelines or regulations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$13,199 )
2025	2024	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	886 CHESTNUT RIDGE ROAD	MORGANTOWN	WV	26505	MONONGALIA	USA	Environmental Health	000	2	3/25/2025	NON-COMPETING CONTINUATION	-$13,199
														Subtotal = -$13,199

Issue Date FY: 2024 ( Subtotal = $21,579 )
2024	2024	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	886 CHESTNUT RIDGE ROAD	MORGANTOWN	WV	26505	MONONGALIA	USA	Environmental Health	001	2	5/27/2024	NON-COMPETING CONTINUATION	-$26,115
2024	2024	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	886 CHESTNUT RIDGE ROAD	MORGANTOWN	WV	26505	MONONGALIA	USA	Environmental Health	000	2	2/7/2024	NON-COMPETING CONTINUATION	$47,694
														Subtotal = $21,579

Issue Date FY: 2022 ( Subtotal = $46,752 )
2022	2022	WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION	886 CHESTNUT RIDGE	MORGANTOWN	WV	26506	MONONGALIA	USA	Environmental Health	000	1	8/30/2022	NEW	$46,752
														Subtotal = $46,752

Grand Total All Awards = $55,132

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Consequences of Maternal Vaping on Cerebrovascular Health in Offspring

Award Number: F31ES034646

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 03/01/2023

PERIOD OF PERFORMANCE END DATE: 05/01/2024

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