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Neurological effects of toxic metal exposure in model rodents collected in zones of industrial agriculture on the U.S.-Mexico border

Award Number: F31ES032299
ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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ABSTRACT Yuma County is a large agricultural hub of the United States and provides over 90% of the winter leafy greens consumed in the U.S. To maintain high agricultural output, more than 2.6 million kilograms of agrichemicals are used in Yuma County each year. These agrichemicals represent a significant exposure source of toxic chemicals for residents, especially the migrant and seasonal farmworkers and those living near agricultural lands. Previous research focused on organic based pesticides and lead exposure sources, but inorganic metals-based pesticides have not been examined in this area. I performed quantitative metal(loid) analysis of human (n = 323) and rodent (Peromyscus eremicus, n = 300) hair samples and found concentrations of neurotoxic metals (especially Cu and Mn) at levels known to be associated with adverse health outcomes. Following these findings, preliminary transcriptomic analyses demonstrated disrupted genetic pathways, including those associated with lipid metabolism and muscle contraction, in the brains of rodents that I captured from agricultural sites, compared to non-agricultural sites, from Yuma County. Cu and Mn are naturally occurring elements and are essential micronutrients in enzymatic reactions, but both are toxic at high concentrations. Cu causes non-specific oxidative damage in tissues, while Mn accumulates in the basal ganglia and dopaminergic neurons and is linked with behavioral issues in children and motor dysfunction in adults. Farmworkers and communities near agricultural areas with high agrichemical application are an understudied population regarding excessive Cu and Mn exposure. This proposal expands upon my preliminary work that identified elevated concentrations of Cu and Mn in human and rodent hair collected in Yuma County by using the P. eremicus rodent model to investigate transcriptomic and lipidomic responses to exposure. Additionally, I am developing a similar approach in collaboration with the Cocopah Tribe in Yuma County to assess the risk of contaminant exposure in their people. Under the guidance of a multidisciplinary team, I aim to: Aim 1) assess effects of mixed metals exposure on brain gene expression in rodents collected from agricultural vs. non-agricultural regions of Yuma County, using both non-targeted Nanostring and targeted qRT-PCR approaches; Aim 2) assess effects of mixed metals exposure on brain metabolic profiles in rodents from these two exposure regions, using liquid chromatography-ion mobility spectrometry-mass spectrometry; and Aim 3) gather P. eremicus samples on Cocopah Tribal Lands to conduct preliminary exposure risk assessment. This project will provide information on the neurological effects of exposure to metals used in agriculture and aid in developing models that assess health impacts in the underserved population of farmworkers and tribal members in Yuma County.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $52,694 )
2024	2024	UNIVERSITY OF ARIZONA	845 N PARK AVE RM 538	TUCSON	AZ	85721	PIMA	USA	Environmental Health	000	3	1/18/2024	NON-COMPETING CONTINUATION	$52,694
														Subtotal = $52,694

Issue Date FY: 2023 ( Subtotal = $52,694 )
2023	2023	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Environmental Health	000	2	1/27/2023	NON-COMPETING CONTINUATION	$51,752
2023	2023	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Environmental Health	001	2	2/16/2023	NON-COMPETING CONTINUATION	$942
														Subtotal = $52,694

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Environmental Health	000	1	1/26/2022	NEW	$0
2022	2021	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Environmental Health	001	1	1/26/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $38,629 )
2021	2021	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Environmental Health	000	1	9/14/2021	NEW	$38,629
														Subtotal = $38,629

Grand Total All Awards = $144,017

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Neurological effects of toxic metal exposure in model rodents collected in zones of industrial agriculture on the U.S.-Mexico border

Award Number: F31ES032299

ORGANIZATION: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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