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Elucidating the role of nonessential amino acid metabolism in diabetic skin wounds

Award Number: F31DK134173
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 03/02/2023
PERIOD OF PERFORMANCE END DATE: 03/01/2027

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Elucidating the role of nonessential amino acid metabolism in diabetic skin wounds - PROJECT SUMMARY Type II diabetes takes a large toll on both individuals and society through morbidity and financial burden. Patients with diabetes are at risk of developing diabetic foot ulcers that are nonhealing and can lead to infections and amputations. The pathophysiology that underlies this impaired wound healing can be due to damage to blood vessels, neurons, and immune function, all of which contribute to delayed wound healing. Normally, skin requires nutrients like nonessential amino acids for building material and energy to undergo repair and heal wounds. My preliminary metabolomics data in different wound regions in control and db/db mice indicate that four nonessential amino acids, including serine and glycine, are particularly depleted in diabetic wounds, suggesting their important biological roles in wound healing. Previous studies of diabetic mice and humans have also found a reduction of serine and glycine within wounds and systemic blood. However, it remains unknown why they are depleted, whether they are required for wound healing, and how they are used for healing. Thus, identification of the cause of their reduction and usage by different cell populations during wound healing in diabetic models will facilitate the future development of new therapeutics. To this end, I will 1) define the distribution and fates of the four nonessential amino acids in different wound regions in healthy and diabetic mice; and 2) determine whether serine and glycine supplementation can promote wound healing. My proposed study will utilize a broad spectrum of innovative tools including in vivo stable isotope tracing coupled with high-resolution mass spectrometry-based metabolomics, microscopy, and cell sorting. This study will expand our understanding of how efficient nutrient utilization facilitates wound healing in normal and diabetic wounds. The findings from this study will also generate important implications regarding potential targets for future pharmacological or genetic knockout experiments in the effort toward developing novel therapies for improving diabetic wound healing.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $55,114 )
2026	2026	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	4	4/3/2026	NON-COMPETING CONTINUATION	$576
2026	2026	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	2/20/2026	NON-COMPETING CONTINUATION	$54,538
														Subtotal = $55,114

Issue Date FY: 2025 ( Subtotal = $54,538 )
2025	2025	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	3	7/14/2025	NON-COMPETING CONTINUATION	$54,538
2025	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	7/9/2025	OTHER REVISION	$0
2025	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	4/29/2025	TERMINATION	$0
														Subtotal = $54,538

Issue Date FY: 2024 ( Subtotal = $44,445 )
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	2	4/26/2024	NON-COMPETING CONTINUATION	$1,280
2024	2024	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	2/8/2024	NON-COMPETING CONTINUATION	$43,165
														Subtotal = $44,445

Issue Date FY: 2023 ( Subtotal = $43,165 )
2023	2023	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	1	3/2/2023	NEW	$0
2023	2023	UNIVERSITY OF CALIFORNIA, IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	3/2/2023	NEW	$43,165
														Subtotal = $43,165

Grand Total All Awards = $197,262

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Elucidating the role of nonessential amino acid metabolism in diabetic skin wounds

Award Number: F31DK134173

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 03/02/2023

PERIOD OF PERFORMANCE END DATE: 03/01/2027

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