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The impact of hearing and vestibular problems on physical function, psychosocial well-being, and survival outcomes among breast cancer survivors

Award Number: F31CA301846
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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The impact of hearing and vestibular problems on physical function, psychosocial well-being, and survival outcomes among breast cancer survivors - PROJECT SUMMARY/ABSTRACT Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer-related mortality among women in the United States. Due to improved survival and the growing aging population, the number of breast cancer survivors has increased, with ~4 million living with breast cancer in 2022. Breast cancer diagnosis and treatment can take a heavy toll on the physical, psychosocial, and financial health of patients, survivors, and their caregivers. Chemotherapy and radiotherapy are widely used to treat breast tumors, with neurosensory consequences. Aging is a significant risk factor for neurosensory dysfunction. Recent literature has suggested a 34-57% prevalence of hearing loss and a 30-60% prevalence of tinnitus among adult cancer survivors who underwent chemotherapy or radiation therapy. Hearing and vestibular problems, such as tinnitus or ringing in the ears, hearing loss, and vertigo or persistent dizziness, are prevalent among older adults and cancer survivors and represent emerging public health concerns in the United States. However, the relationships between hearing and vestibular problems and health outcomes and quality of life specifically among breast cancer patients and survivors are largely unknown. Previous studies are qualitative and descriptive. Additionally, most studies are comprised of mixed cancer types and/or less heterogeneous patient populations, precluding generalizability. Whether hearing loss and vestibular problems are associated with reduced physical function in breast cancer survivors is unclear as is how these conditions affect psychosocial well-being over time and mortality risks of these survivors. The proposed study will address these knowledge gaps by assessing hearing and vestibular problems and their associations with levels of physical function impairment, changes in psychosocial well-being, breast cancer-specific mortality, and all-cause mortality among breast cancer survivors enrolled in the Chicago Multiethnic Epidemiologic Breast Cancer Cohort study. This project will be the largest to date evaluating the relationships between hearing and vestibular problems and physical functioning. It will also be the first to determine their impact on psychosocial well-being over time and the survival of breast cancer survivors. Study findings could help inform the practice of routine screening and early treatment or intervention for hearing and vestibular problems, increase awareness of and patient-provider discussion on these problems, and improve breast cancer survivors' health outcomes and quality of life. The study findings could also provide insight into neurosensory research in survivors of other cancers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $46,473 )
2026	2026	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cancer Research Manpower	001	1	5/14/2026	NEW	$0
2026	2026	UNIVERSITY OF CHICAGO	5801 S ELLIS AVE	CHICAGO	IL	60637	COOK	USA	Cancer Research Manpower	000	1	5/14/2026	NEW	$46,473
														Subtotal = $46,473

Grand Total All Awards = $46,473

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The impact of hearing and vestibular problems on physical function, psychosocial well-being, and survival outcomes among breast cancer survivors

Award Number: F31CA301846

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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