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Factors Impacting Global Health: The Importance of Individualized Treatment Goals for Black Breast Cancer Survivors

Award Number: F31CA294988
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/01/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Factors Impacting Global Health: The Importance of Individualized Treatment Goals for Black Breast Cancer Survivors - This F31 award will allow Kelsey Sinclair (PI) the research training that will advance her toward her goal of becoming an independent cancer multimorbidity scientist with an expertise in intervention adaptation and implementation to optimize cancer care in underserved groups. Cancer-obesity co-morbidity is common and especially deadly for Black breast cancer survivors (BCS). Although Black women have lower breast cancer incidence, they have the highest breast cancer mortality rate (40%) of any U.S. race/ethnic group – an effect attributed to comorbid obesity. Obesity predicts higher mortality among Black BCS, and post-cancer diagnosis weight gain predicts increases in mortality. One way to fight back against the effects of obesity is to develop and to deliver obesity treatments adapted to address the unique challenges of the BCS community. Identification of important risk/protective factors can be applied to evidence-based weight loss interventions to provide potentially life-extending care. The proposed multi-method study will use a socioeconomic framework and multi-methods to discover actual risk/protective factors for Black BCS with obesity compared to other BCS. PI Sinclair will leverage resources from a parent trial to first use a quantitative survey to assess 100 BCS from any race-ethnicity to test potential risk and protective factors that differ for Black BCS (Phase 1). Second, using co-design qualitative methods, initial tailoring of an evidence-based weight loss intervention for obesity will be done in collaboration with our patient partners – five Black BCS with obesity (Phase 2). This tailored weight loss protocol will then be delivered in a pilot with 15 Black BCS with obesity, with preliminary evaluation of potential treatment heterogeneity factors (Phase 3). Via these phases, the following F31 aims will be addressed: Aim 1: To proactively identify lifestyle and multimorbid factors of an obesity intervention for Black BCS and Exploratory Aim 2: To explore obesity treatment response in Black BCS via subgroup analyses. The proposed F31 will thus utilize Phase 1 survey data and Phase 2 qualitative interviews (Aim 1) as well as Phase 3 post-treatment data (Exploratory Aim 2). Accordingly, it will benefit from the existing parent pilot infrastructure (e.g., recruitment strategies, participants, trial conduct). For the parent trial, the outcomes are acceptability, feasibility, and preliminary weight loss of the program. PI Sinclair’s project and training plan will allow for a comprehensive multi-method analysis of adaptation factors to inform future larger-scale trials and foundations of a future F32 or K23 for PI Sinclair, a future scholar with expertise in multimorbidity interventions in cancer, obesity, and other chronic diseases differently impacting breast cancer survivors.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $38,352 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Cancer Research Manpower	000	2	8/5/2025	NON-COMPETING CONTINUATION	$38,352
														Subtotal = $38,352

Issue Date FY: 2024 ( Subtotal = $37,788 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Cancer Research Manpower	000	1	7/16/2024	NEW	$37,788
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	107 S INDIANA AVE	BLOOMINGTON	IN	47405	MONROE	USA	Cancer Research Manpower	001	1	7/16/2024	NEW	$0
														Subtotal = $37,788

Grand Total All Awards = $76,140

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Factors Impacting Global Health: The Importance of Individualized Treatment Goals for Black Breast Cancer Survivors

Award Number: F31CA294988

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/01/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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