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Development and Validation of an Implementation Penetration Assessment Criteria Tool (ImPACT-HPV) for HPV Vaccination in Nigeria

Award Number: F31CA294971
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/05/2025
PERIOD OF PERFORMANCE END DATE: 02/04/2027

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Development and Validation of an Implementation Penetration Assessment Criteria Tool (ImPACT-HPV) for HPV Vaccination in Nigeria - There exists a research-to-practice gap that hinders the penetration of human papillomavirus (HPV) vaccination among adolescent girls and young women in Nigeria. To close this gap requires reliable, validated, easy-to-use tools to identify and measure elements of penetration that drive high performance of HPV vaccination uptake in resource limited settings. Penetration, defined here as the integration of evidence (i.e. HPV vaccines) within the culture of recipient setting or community through policies and practices remains incompletely understood in low resource settings. Currently, existing measures for penetration suggest that there are three stages that determine the extent of integration within service settings: 1) passages (i.e. single event); 2) routines (repetitive reinforcement of interventions) and 3) niche saturation (or extent in which intervention is integrated). However, these measures often confound several dynamic processes inherent with integrating evidence-based interventions within resource limited settings. They also provide no insight on the multidimensional nature of penetration or whether it may be influenced by important determinants such as: 1) perceptions of passages; 2) enablers or resources for routines; and 3) nurturers or assets for niche saturation. In response to NCI’s Strategic Plan to advance cancer prevention research and increase HPV vaccination coverage. The overall goal of this F31 is to develop a reliable, valid, and pragmatic assessment tool to identify core features of penetration related to high uptake of HPV vaccines. We proposed to develop the Implementation Penetration Assessment Criteria Tool (ImPACT) with the guidance of the perceptions, enablers, and nurturers domain of the PEN-3 cultural model developed by Airhihenbuwa to address the determinants highlighted above. This study, which builds on the recently funded ACCESS study (R01 CA271033: PI: Iwelunmor: Actions for Collaborative Community Engages Strategies for HPV), will develop the ImPACT Tool through the projects three specific aims: to (1) identify core domains and items that will comprise an Implementation Penetration Assessment Criteria Tool (ImPACT) via in-depth interviews with 20 young women and group concept mapping with 20 key stakeholders; (2) evaluate face validity of the ImPACT tool via cognitive interviewing and pilot test the drafted tool; and (3) evaluate the psychometric properties of the ImPACT tool across 18 sites of the ACCESS study using the Psychometric Evidence Scale criteria as a guide. The project is significant because, if successful, it would be the first reliable, valid, and pragmatic instrument for assessing the penetration of evidence-based HPV vaccination in low resource settings and will also provide a roadmap for building capacity and infrastructure for advancing the reach, adoption, and sustainability of HPV vaccination programs. This project will also prepare the applicant to become a leading independent researcher in the field of implementation science and support training in rigorous, solution oriented implementation research focused on improving population health outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $37,941 )
2026	2026	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Research Manpower	001	2	4/16/2026	NON-COMPETING CONTINUATION	$576
2026	2026	WASHINGTON UNIVERSITY, THE	1 BROOKINGS DR	SAINT LOUIS	MO	63130	SAINT LOUIS	USA	Cancer Research Manpower	000	2	2/25/2026	NON-COMPETING CONTINUATION	$37,365
														Subtotal = $37,941

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Cancer Research Manpower	000	1	11/14/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $36,801 )
2024	2024	WASHINGTON UNIVERSITY, THE	ONE BROOKINGS DR	SAINT LOUIS	MO	63110	SAINT LOUIS CITY	USA	Cancer Research Manpower	000	1	8/5/2024	NEW	$36,801
														Subtotal = $36,801

Grand Total All Awards = $74,742

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Development and Validation of an Implementation Penetration Assessment Criteria Tool (ImPACT-HPV) for HPV Vaccination in Nigeria

Award Number: F31CA294971

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/05/2025

PERIOD OF PERFORMANCE END DATE: 02/04/2027

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