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Identification of the Role of FlgW in the Biogenesis of the fT3SS in Campylobacter jejuni

Award Number: F31AI186490
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/01/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2026

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Identification of the Role of FlgW in the Biogenesis of the fT3SS in Campylobacter jejuni - Project Summary The bacterial flagellum is a complex nanomachine that functions as a motor to promote bacterial swimming through environments and is essential for colonization of many pathogens to promote disease. Flagellar biogenesis begins with the assembly of the flagellar type III secretion system (fT3SS), which is functionally and evolutionarily related to the injectisome T3SS (iT3SS) of many pathogens. Despite the structural similarities of the flagellar and injectisome T3SSs, unique proteins are employed to build each system for the creation of flagella or injectisomes. In addition, the model organisms Salmonella species or E. coli fail to account for the diversity of components and molecular mechanisms required for flagellar biogenesis across bacterial species. Polar flagellates, including Campylobacter jejuni¸ Vibrio cholerae, Pseudomonas aeruginosa, and Helicobacter pylori, require additional regulatory components to construct fT3SS in strict numbers and only at the cell poles. We found that C. jejuni utilizes a unique protein to impact the formation of the fT3SS for flagellar biogenesis. The major goal of this proposal, using structural, molecular, and biochemical approaches, will be to characterize molecular mechanisms of the components required to build the fT3SS in C. jejuni. To achieve this, the applicant will be advised by a mentoring team that includes a sponsor and dissertation committee with a wide range of expertise including bacteriology, genetics, structural biology, protein biochemistry, and molecular biology. The collaboration between the candidate and sponsor provides her with mentorship that is unique, interdisciplinary, and allows for the opportunity to develop skills that will be utilized throughout the entirety of her academic career, from post-doc to independent researcher. The resources, facilities, equipment, and faculty available at UT Southwestern Medical Center far exceed the needs of the proposal, ensuring a successful training environment to complete the following aims. In Aim 1, I will analyze the structure of the fT3SS and formation of large ring structures within the fT3SS in WT C. jejuni and isogenic mutants. In Aim 2, I will characterize the molecular mechanisms of flagellar proteins to promote fT3SS assembly in C. jejuni. Completion of this project will: 1) contribute to the diversity of components required to build T3SSs, and 2) expand on the molecular mechanisms of biogenesis of the fT3SS in polarly flagellated pathogens.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $41,049 )
2026	2026	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Allergy and Infectious Diseases Research	000	2	1/14/2026	NON-COMPETING CONTINUATION	$41,049
														Subtotal = $41,049

Issue Date FY: 2024 ( Subtotal = $40,127 )
2024	2024	THE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER	5323 HARRY HINES BLVD	DALLAS	TX	75390	DALLAS	USA	Allergy and Infectious Diseases Research	000	1	6/19/2024	NEW	$40,127
														Subtotal = $40,127

Grand Total All Awards = $81,176

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Identification of the Role of FlgW in the Biogenesis of the fT3SS in Campylobacter jejuni

Award Number: F31AI186490

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/01/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2026

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