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Connectomic Dysfunction Underlying Cognitive Impairment in Alcohol Use Disorder and the Link to Alzheimer?s Disease

Award Number: F31AA030217
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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Project Summary/Abstract Alzheimer’s Disease (AD) and Alcohol Use Disorder (AUD) are two disorders that share a high cost of degraded life quality, high mortality, and poor prognosis. Recent evidence suggests that AUD is a risk factor for AD though the exact relationship between the two disorders is unknown. The proposed study aims to elucidate this relationship by determining which functional neuropathologies are associated with cognitive decline in AUD and mild cognitive impairment (MCI), a cognitive pathology which frequently precedes dementia. This project will collect resting and task-based fMRI data from AUD participants and use existing data from MCI and healthy controls (HC). The two task paradigms consist of an episodic memory encoding task and a spatial working-memory task. The resting-state data will be used to extract the default mode network, the episodic memory encoding task data will be used to extract the episodic memory network, and the spatial working- memory task data will be used to extract the spatial working-memory network. Graph-theory metrics will be used to characterize connectome profiles associated with cognitive impairment, as measured by Montreal Cognitive Assessment (MoCA) score. The primary hypotheses are that graph-theory features of the episodic memory network and/or the default mode networks in healthy controls will show alterations in the AUD and MCI group and that these alterations are associated with MoCA score. The exploratory hypothesis is that graph-theory scores of the spatial working-memory network will be associated with MoCA score in AUD subjects. If the hypotheses are confirmed it could provide initial evidence that AUD increases the risk of AD through cognitive impairment that results from compounding mild pre-existing deficits in at-risk individuals. Such evidence could guide future treatments for both disorders by elucidating novel treatment targets which could stop or slow the progression of cognitive decline.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $46,429 )
2024	2024	THE MEDICAL UNIVERSITY OF SOUTH CAROLINA	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	001	2	5/1/2024	NON-COMPETING CONTINUATION	$1,280
2024	2024	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	2	11/1/2023	NON-COMPETING CONTINUATION	$45,149
														Subtotal = $46,429

Issue Date FY: 2022 ( Subtotal = $44,207 )
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	001	1	9/13/2022	NEW	$0
2022	2022	MEDICAL UNIVERSITY OF SOUTH CAROLINA THE	179 ASHLEY AVE	CHARLESTON	SC	29425	CHARLESTON	USA	Alcohol Research Programs	000	1	9/13/2022	NEW	$44,207
														Subtotal = $44,207

Grand Total All Awards = $90,636

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Connectomic Dysfunction Underlying Cognitive Impairment in Alcohol Use Disorder and the Link to Alzheimer?s Disease

Award Number: F31AA030217

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

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