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Developmental transcriptomics of the Paraventricular Thalamus

Award Number: F30MH143517
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2029

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Developmental transcriptomics of the Paraventricular Thalamus - Abstract: Early life adversity (ELA) is a strong risk factor for poor mental health, which affects up to 20% of individuals worldwide. Human studies document this strong association, but do not allow for establishing direct causality, timing, and mechanisms linking ELA to subsequent mental health disorders. Rodent models allow for rapid brain maturation and controlled experiments establishing causality and investigating mechanisms. We established a naturalistic rodent model of ELA which leads to enduring disruption of adult reward behaviors including anhedonia, recapitulating key features of ELA-linked human phenotypes and thus providing a framework for investigating mechanisms linking ELA and mental illness. Using this model, we discovered that among all brain regions studied, only the paraventricular nucleus of the thalamus (PVT) distinguished ELA from control rearing conditions with much higher neuronal activation. In addition, DREADD inhibition of these ELA-activated PVT cells mitigates ELA-induced aberrant behaviors in adult mice. These findings point to the PVT as a key brain region that encodes ELA and contributes to the execution of its effects on adult motivated behaviors. However, it is unknown which cells in the heterogenous PVT are selectively activated by ELA, when and or how developmental programs of the PVT are disrupted by ELA, and whether homologous cell types exist between mouse and human PVT. The aims of this proposal address these questions with cutting edge technical and analytic tools at single-cell resolution.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $47,383 )
2026	2026	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	001	1	8/7/2026	NEW	$0
2026	2026	UNIVERSITY OF CALIFORNIA IRVINE	160 ALDRICH HALL	IRVINE	CA	92697	ORANGE	USA	Mental Health Research Grants	000	1	8/7/2026	NEW	$47,383
														Subtotal = $47,383

Grand Total All Awards = $47,383

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Developmental transcriptomics of the Paraventricular Thalamus

Award Number: F30MH143517

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2029

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