Thursday, September 18, 2025 9/18/2025

The Effect of Pubertal Hormones on the Development of Neural Oscillatory Dynamics in Youth

Award Number: F30MH130150
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/13/2024
PERIOD OF PERFORMANCE END DATE: 09/12/2026

Group Awards By:

View Award Description

The Effect of Pubertal Hormones on the Development of Neural Oscillatory Dynamics in Youth - Project Summary This application describes the research plan and program of study leading to a PhD as part of a combined MD- PhD Program at the University of Nebraska Medical Center and the Boys Town National Research Hospital. The central goal of this research plan is to identify how dehydroepiandrosterone (DHEA), testosterone, and estradiol modulate the development of cognitive systems serving selective attention and working memory processing. Briefly, the pubertal transition period is marked by significant increases in these hormones and substantial developmental advancements in higher-order cognitive functions, including working memory, selective attention, and others. However, on the other hand, the incidence of psychiatric disease also increases during puberty, and is accompanied by greater sex differences in disease prevalence. It has been suggested that this emergence of psychiatric illness during puberty might be associated with the drastic hormonal changes that mark this developmental stage, but the net impact of these hormonal changes on brain function and cognition is poorly understood. This F30 fellowship proposal will examine the sex and region-specific effects of DHEA, testosterone, and estradiol on working memory and selective attention processing using an advanced dynamic functional mapping approach based on magnetoencephalography (MEG), and includes a rigorous training and career development plan for a future physician-scientist in the areas of pediatric psychiatry and developmental cognitive neuro- science. The specific aims are (1) to examine the unique effects of pubertal hormones in predicting performance on selective attention and working memory tasks and (2) to identify the relationship between sex steroid hormone levels, neural oscillatory dynamics, and behavior during attention and working memory tasks. The trainee is a minority MD/PhD student in his 2nd year of PhD study who has already distinguished himself through two first- authored manuscripts in top journals, participation and presentation in scientific conferences, and a strong history of academic achievement. In sum, this application for an F30 fellowship will use MEG, advanced source reconstruction methods, neural oscillatory analyses, and hair-sampled hormone analysis to delineate the relationship between pubertal hormone levels, brain dynamics, and cognitive development. The program of study is designed to support this research plan through rigorous training by an internationally known expert in MEG and dynamic brain mapping who has a strong record of mentoring trainees, as well as an expert collaborator in pubertal hormone analysis and interpretation, with the primary goals of developing and expanding the research and clinical skills of the applicant to produce a physician-scientist who is well equipped and prepared for the next stage of his career.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $16,228 )
2025	2025	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	4215 EMILE ST	OMAHA	NE	68105	DOUGLAS	USA	Mental Health Research Grants	002	4	9/4/2025	NON-COMPETING CONTINUATION	$54,538
2025	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	4215 EMILE ST	OMAHA	NE	68105	DOUGLAS	USA	Mental Health Research Grants	001	3	8/6/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2025	2023	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	000	2	7/25/2025	NON-COMPETING CONTINUATION	-$38,310
														Subtotal = $16,228

Issue Date FY: 2024 ( Subtotal = $53,974 )
2024	2024	BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA	987835 NEBRASKA MEDICAL CENTER	OMAHA	NE	68198	DOUGLAS	USA	Mental Health Research Grants	001	3	8/20/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$53,974
2024	2023	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	000	2	8/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $53,974

Issue Date FY: 2023 ( Subtotal = $42,590 )
2023	2023	FATHER FLANAGAN'S BOYS' HOME	14100 CRAWFORD ST	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	000	2	8/22/2023	NON-COMPETING CONTINUATION	$42,590
														Subtotal = $42,590

Issue Date FY: 2022 ( Subtotal = $41,648 )
2022	2022	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	000	1	9/13/2022	NEW	$41,648
2022	2022	FATHER FLANAGAN'S BOYS' HOME	13603 FLANAGAN BLVD	BOYS TOWN	NE	68010	DOUGLAS	USA	Mental Health Research Grants	001	1	9/13/2022	NEW	$0
														Subtotal = $41,648

Grand Total All Awards = $154,440

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The Effect of Pubertal Hormones on the Development of Neural Oscillatory Dynamics in Youth

Award Number: F30MH130150

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/13/2024

PERIOD OF PERFORMANCE END DATE: 09/12/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer