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Compliant Limb Reconstruction: Co-engineering Body and Machine to Revolutionize Limb Salvage

Award Number: DP2HD111538
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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Compliant Limb Reconstruction: Co-engineering Body and Machine to Revolutionize Limb Salvage - PROJECT SUMMARY My long-term goal is to reconstruct limbs that have lost function due to injury or disease. To achieve this goal, my research program combines surgical and mechanical design in a paradigm called anatomics, in which body and machine are co-engineered in pursuit of superior bionic performance. In this proposal, I apply an anatomics- centered approach to the surgical treatment of limb pathology. The human body is made up of compliant (“flexible”) structures that are fundamental to basic function. Joints, the highly-compliant structures that link bones together, are perhaps the most important of these structures for human movement. The nuanced relationships between load and deformation (called “compliance”) in joint tissues dictate how internal and external forces are converted to limb motion. Disruption of inherent biological compliance is often devastating to the body’s ability to move in a healthy way. This disruption can occur as a result of injury or disease, or even the reconstructive procedures intended to alleviate limb pathology. In severe cases, the pain and disability caused by changes to limb compliance are so intense, and treatment options so limited, that patients choose to amputate their viable but dysfunctional limb in search of relief. Unfortunately, there is currently no way to correct the compliance of biological joints and tissues when they are disrupted; this creates enormous challenges for the increasing number of patients with limb pathology, who are often left to live with limbs that are viable but non- functional. In response to this need, I propose a novel class of compliant implantable prostheses that would enable pathological joint compliance to be corrected, and function restored. With support from the New Innovator Award, I will advance a novel compliant limb reconstruction (CLR) pipeline capable of generating joint-and- pathology-specific implant mechanics, and apply this pipeline to design implants for two limb pathologies with urgent unmet clinical needs. I will then fabricate and validate these implants, collecting critical data to support early feasibility studies in human subjects. This work will form the foundation for future initiatives supporting refinement of the CLR pipeline, and is the first step toward a research program that uses the approach to target many different pathologies across all of the body’s joints. I expect that the proposed research will transform the clinical paradigm for treatment of limb pathology, opening the door to revolutionary new salvage options that alleviate pain, restore function, and prevent amputation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Child Health and Human Development Extramural Research	001	2	4/7/2026	EXTENSION WITH OR WITHOUT FUNDS	$0
2026	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	1	3/19/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $1,038,116 )
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Child Health and Human Development Extramural Research	001	2	8/28/2025	EXTENSION WITH OR WITHOUT FUNDS	$945,000
2025	2025	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	1	12/23/2024	SUPPLEMENT FOR EXPANSION	$93,116
														Subtotal = $1,038,116

Issue Date FY: 2022 ( Subtotal = $1,404,000 )
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Child Health and Human Development Extramural Research	001	1	9/21/2022	NEW	$0
2022	2022	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Child Health and Human Development Extramural Research	000	1	9/8/2022	NEW	$1,404,000
														Subtotal = $1,404,000

Grand Total All Awards = $2,442,116

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Compliant Limb Reconstruction: Co-engineering Body and Machine to Revolutionize Limb Salvage

Award Number: DP2HD111538

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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