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Building a map of cell type specific nutrient use across mammalian tissues

Award Number: DP2AT014320
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2031

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Building a map of cell type specific nutrient use across mammalian tissues - PROJECT SUMMARY Diet and exercise are common ways to try and improve health. Yet, our understanding of how diet and exercise influence biology at the cellular level is limited. This is in part because many of the impacts of diet and exercise are facilitated by changes in metabolism, and metabolism is hard to study at the cellular level in physiological contexts. Here we develop a method to measure cell type specific metabolism in vivo and in ex vivo culture systems. We propose to use this new method to characterize cell type specific nutrient use across all major cell types within the liver and the pancreas. We aim to perform these experiments in both live mice by doing in vivo stable isotope tracing and on ex vivo cultured human tissue. Then, we propose to interface our methodologic approach with proteomics to expand our measurements across all mammalian tissues with the goal of deepening our understanding of which cell types are most reliant on what nutrients. These studies will not only provide invaluable data to aid in our understanding of how nutrients are used in the body, but will provide a new method to enable mechanistic studies into how nutrients support cell function in a cell type specific manner.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $741,000 )
2026	2026	UNIVERSITY OF CALIFORNIA, LOS ANGELES	10889 WILSHIRE BLVD STE 700	LOS ANGELES	CA	90024	LOS ANGELES	USA	Trans-NIH Research Support	000	1	9/10/2026	NEW	$741,000
														Subtotal = $741,000

Grand Total All Awards = $741,000

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Building a map of cell type specific nutrient use across mammalian tissues

Award Number: DP2AT014320

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2031

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