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NIH DIRECTOR'S PIONEER AWARD

Award Number: DP1OD000805
ORGANIZATION: OFFICE OF THE DIRECTOR, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/20/2009
PERIOD OF PERFORMANCE END DATE: 09/30/2011

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NIH DIRECTOR'S PIONEER AWARD - The research proposed has two complementary goals. The first goal is to elucidate the biological properties of adult stem cells (ASCs) that renew human tissues. The second is to translate human ASC discoveries into advances in cellular medicine. For decades, lack of critical knowledge about ASCs has been a formidable wall at the frontier of ASC research and cellular medicine. Three intractable research challenges form this wall. Methods for exact identification of ASCs are lacking, ASCs are difficult to produce in large quantities, and, therefore, important biological features of ASCs remain obscure. To address these challenges, during the past 14 years as a principal investigator, the applicant undertook research with genetically-engineered mouse cells that modeled essential unique properties of ASCs. These properties are asymmetric self-renewal and immortal DNA strand co-segregation, two defining features of ASCs. A series of reports from the applicant?s laboratory established the relevance of discoveries made with the mouse ASC models to rodent ASCs in vivo. These discoveries established an innovative foundation for identifying ASCs, expanding ASCs in culture, and investigating ASC cellular and molecular properties. With NDPA support, the applicant will change the direction of his research program, forged with rodent ASC studies, to focus on human ASCs and their conversion into embryonic stem cell (ESC)-like cells. Human ASCs responsible for liver, hematopoietic cells, pancreas, and hair will be the focus of research with the goal of developing both pre-clinical and clinical applications for cellular medicine. The applicant?s research program enjoys collaborations with several laboratories from diverse scientific disciplines and technological fields, including mathematics, chromosome biology, mass spectrometry, bioinformatics, genomics, electrical engineering, computer sciences, and the cell products industry. These interactions will complement research to expand selected human ASCs, develop tools for their exact identification, and advance ASCs as effective cellular medicines for human disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2011 ( Subtotal = $0 )
2011	2009	BOSTON BIOMEDICAL RESEARCH INSTITUTE	64 GROVE STREET	WATERTOWN	MA	02472	MIDDLESEX	USA	Trans-NIH Recovery Act Research Support	000	3	11/5/2010	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2010 ( Subtotal = $1,015,000 )
2010	2010	BOSTON BIOMEDICAL RESEARCH INSTITUTE	64 GROVE STREET	WATERTOWN	MA	02472	MIDDLESEX	USA	Trans-NIH Research Support	000	5	8/30/2010	NON-COMPETING CONTINUATION	$1,015,000
														Subtotal = $1,015,000

Issue Date FY: 2009 ( Subtotal = $1,062,096 )
2009	2009	BOSTON BIOMEDICAL RESEARCH INSTITUTE	64 GROVE STREET	WATERTOWN	MA	02472	MIDDLESEX	USA	Trans-NIH Recovery Act Research Support	000	3	7/10/2009	SUPPLEMENT FOR EXPANSION	$47,096
2009	2009	BOSTON BIOMEDICAL RESEARCH INSTITUTE	64 GROVE STREET	WATERTOWN	MA	02472	MIDDLESEX	USA	Trans-NIH Research Support	001	4	8/13/2009	NON-COMPETING CONTINUATION	$1,015,000
														Subtotal = $1,062,096

Issue Date FY: 2008 ( Subtotal = $995,000 )
2008	2008	BOSTON BIOMEDICAL RESEARCH INSTITUTE	64 GROVE STREET	WATERTOWN	MA	02472	MIDDLESEX	USA	Trans-NIH Research Support	000	3	7/28/2008	NON-COMPETING CONTINUATION	$995,000
														Subtotal = $995,000

Issue Date FY: 2007 ( Subtotal = $995,000 )
2007	2007	BOSTON BIOMEDICAL RESEARCH INSTITUTE	64 GROVE STREET	WATERTOWN	MA	02472	MIDDLESEX	USA	Academic Research Enhancement Award	000	2	9/17/2007	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$995,000
														Subtotal = $995,000

Issue Date FY: 2006 ( Subtotal = $825,001 )
2006	2006	MASSACHUSETTS INSTITUTE OF TECHNOLOGY	77 MASS AVE, BLDG E19-583	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Academic Research Enhancement Award	000	1	9/28/2006	NEW	$825,001
														Subtotal = $825,001

Grand Total All Awards = $4,892,097

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NIH DIRECTOR'S PIONEER AWARD

Award Number: DP1OD000805

ORGANIZATION: OFFICE OF THE DIRECTOR, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/20/2009

PERIOD OF PERFORMANCE END DATE: 09/30/2011

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