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Novel Proteomics Approach to HIV-Associated Neurocognitive Disorder & Drug Abuse

Award Number: DP1DA041722
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By Issue Date FY or Funding FY:

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¿ DESCRIPTION (provided by applicant):Emerging evidence suggests the heuristic model that both HIV/AIDS and several forms of drug abuse affect the brain via free radical damage involving the generation of reactive oxygen species (ROS, producing oxidative stress) and reactive nitrogen species (RNS) such as nitric oxide (NO, resulting in nitrosative stress). For example, both HIV- associated neurocognitive disorder (HAND) and methamphetamine appear to produce neuronal damage via oxidative and nitrosative stress (Cadet and Krasnova, 2007). However, the cellular and molecular targets of this free radical stress remain largely unknown. These unknown protein targets are a major challenge for the field and need to be identified in order to develop both Biomarkers of disease and to allow screening for new therapies to prevent corruption of these targets by free radical stress. Here, I propose an innovative approach using newly emerging Mass Spectrometry (MS) techniques to identify the posttranslational modifications (PTMs) of proteins resulting from such nitrosative- and oxidative-induced redox stress and hence identify new protein targets affected by AIDS and drug abuse. Heretofore, it has not been possible to identify the full range of proteins undergoing PTMs due to nitrosative and oxidative stress, but new MS techniques should allow this identification. These newly identified target proteins are expected to serve as Biomarkers of the disease process and also should allow us to direct future therapeutic intervention by discovering new pathogenic pathways.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$141,324 )
2024	2020	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	001	6	11/20/2023	SUPPLEMENT FOR EXPANSION	-$39,468
2024	2020	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	000	6	11/20/2023	NON-COMPETING CONTINUATION	-$86,066
2024	2020	SCRIPPS RESEARCH INSTITUTE	10550 N TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	002	6	11/20/2023	SUPPLEMENT FOR EXPANSION	-$15,790
														Subtotal = -$141,324

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	000	6	1/24/2022	NON-COMPETING CONTINUATION	$0
2022	2017	SCINTILLON INSTITUTE	6868 NANCY RIDGE DR	SAN DIEGO	CA	92121	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	001	2	9/12/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $1,588,672 )
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	001	6	4/17/2020	SUPPLEMENT FOR EXPANSION	$177,500
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	000	6	2/24/2020	NON-COMPETING CONTINUATION	$967,500
2020	2020	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	002	6	6/19/2020	SUPPLEMENT FOR EXPANSION	$443,672
														Subtotal = $1,588,672

Issue Date FY: 2019 ( Subtotal = $1,547,843 )
2019	2019	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	002	5	6/20/2019	SUPPLEMENT FOR EXPANSION	$483,750
2019	2019	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	001	5	3/4/2019	NON-COMPETING CONTINUATION	$1,064,093
2019	2018	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	000	4	2/4/2019	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $1,547,843

Issue Date FY: 2018 ( Subtotal = $1,650,255 )
2018	2018	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	007	4	8/31/2018	SUPPLEMENT FOR EXPANSION	$483,568
2018	2018	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	004	4	4/26/2018	NON-COMPETING CONTINUATION	$116,069
2018	2018	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	002	4	2/20/2018	NON-COMPETING CONTINUATION	$1,044,618
2018	2018	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	003	4	3/2/2018	NON-COMPETING CONTINUATION	$0
2018	2017	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	006	3	5/3/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$141,324
2018	2017	SCINTILLON INSTITUTE,THE	6868 NANCY RIDGE DR	SAN DIEGO	CA	92121	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	000	2	12/7/2017	NON-COMPETING CONTINUATION	-$512,321
2018	2017	SCINTILLON INSTITUTE,THE	6868 NANCY RIDGE DR	SAN DIEGO	CA	92121	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	005	2	5/3/2018	NON-COMPETING CONTINUATION	-$141,324
2018	2017	SCRIPPS RESEARCH INSTITUTE, THE	10550 NORTH TORREY PINES RD	LA JOLLA	CA	92037	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	001	3	12/7/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$518,321
														Subtotal = $1,650,255

Issue Date FY: 2017 ( Subtotal = $1,231,185 )
2017	2017	SCINTILLON INSTITUTE,THE	6868 NANCY RIDGE DR	SAN DIEGO	CA	92121	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	002	2	5/22/2017	NON-COMPETING CONTINUATION	$113,580
2017	2017	SCINTILLON INSTITUTE,THE	6404 NANCY RIDGE DR	SAN DIEGO	CA	92121	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	000	1	1/13/2017	SUPPLEMENT FOR EXPANSION	$95,395
2017	2017	SCINTILLON INSTITUTE,THE	6404 NANCY RIDGE DR	SAN DIEGO	CA	92121	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	001	2	3/2/2017	NON-COMPETING CONTINUATION	$1,022,210
														Subtotal = $1,231,185

Issue Date FY: 2016 ( Subtotal = $945,000 )
2016	2016	THE SCINTILLON INSTITUTE	6404 NANCY RIDGE DRIVE	SAN DIEGO	CA	92121	SAN DIEGO	USA	Drug Abuse and Addiction Research Programs	000	1	3/25/2016	NEW	$945,000
														Subtotal = $945,000

Grand Total All Awards = $6,821,631

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Novel Proteomics Approach to HIV-Associated Neurocognitive Disorder & Drug Abuse

Award Number: DP1DA041722

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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