Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Leveraging North-South Partnerships toAdvance Cell and Gene Therapy for HIV Research Training Capacity in Uganda (C and GT-Uganda)

Award Number: D43TW013052
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2025
PERIOD OF PERFORMANCE END DATE: 03/31/2030

Group Awards By:

View Award Description

Leveraging North-South Partnerships toAdvance Cell and Gene Therapy for HIV Research Training Capacity in Uganda (C and GT-Uganda) - PROJECT SUMMARY/ABSTRACT According to the United Nations Progamme on HIV/AIDS, the global response to HIV/AIDS is described as “in Danger” considering current trends, meaning that attaining epidemic control by 2030 is unlikely. As of 2021, 45% of the 1.5 million new cases of HIV and 43% of the 650,000 deaths from AIDS globally were in sub-Saharan Africa. Despite availability of successful antiretroviral therapy, many do not have access or are unable to adhere to this treatment for life. While seven people have so far been functionally cured of HIV using allogeneic blood stem cell transplant techniques (all in high-income countries), this treatment is predicted to be useful for <1% of people living with HIV globally. Moreover, these individuals were treated with allogeneic transplant for a cancer diagnosis. In the absence of cancer, the risk-to-benefit ratio of such a treatment is not justified. A novel approach to HIV cure which could be applied in people living with HIV who do not have cancer would be transformative to epidemic control. Genetic engineering techniques (i.e. gene therapy) can be used to make blood cell treatment more widely available, since genetic engineering can be done on the patient’s own blood cells without the need of a donor. Indeed, more than 46 clinical trials for some kind of gene therapy to treat HIV have been registered to date. However, none of these has been conducted in sub-Saharan Africa, nor has the research and development of these approaches included African researchers or Africans living with HIV. To address this gap, capacity for cell and gene therapy research towards HIV cure must be built locally. This proposal leverages the expertise of Ugandan institutions which have led the HIV response in education, training, research and clinical intervention to develop personnel (i.e. manpower), research, advocacy and excellence in cell and gene therapy for HIV cure in partnership with leading institutions in the U.S. actively developing these treatments. To achieve capacity in Uganda, this proposal will train both degree and non-degree fellows in cell and gene therapy through courses, research training both locally and internationally, and in certificate conferring and informational webinars and short courses. Trainees will be part of a growing global cell and gene therapy network to build partnerships between the global north and south, to create foundations for advocacy and policy needed to implement cell and gene therapy, and to foster a center of excellence which will allow dissemination of cell and gene therapy for HIV cure to other countries in sub-Saharan Africa. Altogether, this training grant will build critical capacity for cell and gene therapy for HIV cure in the places where it is most needed, and where it’s success will most likely translate to a more meaningful global response to the HIV epidemic.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $268,665 )
2025	2025	JOINT CLINICAL RESEARCH CENTRE	LUBOWA HILL PLOT 101 ENTEBBE ROAD	KAMPALA				UGA	International Research and Research Training	000	1	7/1/2025	NEW	$268,665
														Subtotal = $268,665

Grand Total All Awards = $268,665

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Leveraging North-South Partnerships toAdvance Cell and Gene Therapy for HIV Research Training Capacity in Uganda (C and GT-Uganda)

Award Number: D43TW013052

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2025

PERIOD OF PERFORMANCE END DATE: 03/31/2030

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer