This application seeks funding for a D43 training grant to support a world-first rheumatic heart disease
(RHD) research training program in Uganda. There has been little innovation globally in RHD prevention,
early detection, and management since the mid-1900’s. Additionally, the majority of evidence guiding
current practice was generated in high-income countries and may not translate directly to the contemporary
burden of disease in low- and middle-income countries (LMICs). The Impact Mentored Research-Training
Program will leverage existing resources and ongoing RHD clinical trials from a decade-long RHD research
and training collaboration between Makerere University, the Uganda Heart Institute (UHI), Cincinnati
Children’s Hospital Medical Centre (CCHMC) and Children’s National Hospital (CNH) to build capacity to
tackle RHD where the burden is the highest. Our overarching objective is to equip and nurture emerging
research leaders and professional scholars in Uganda to generate high-quality contemporary evidence on
RHD across the lifespan and to create an enduring research training center on the African continent that
will rapidly advance progress towards the elimination of the disease in a generation; a bold, but achievable
goal. This application will provide critical support for the training, and research activities needed to realize
this vision. The program will be led by Dr. Nelson Sewankambo, a Professor of Medicine
and Former Dean of the Makerere University School of medicine, who has led several NIH and non-NIH
research capacity building grants in Uganda and sub-Saharan Africa. Co-directing this program are the co-
Directors of the Rheumatic Heart Disease Research Collaborative in Uganda (RRCU), Drs. Emmy Okello
(UHI) and Andrea Beaton (CCHMC). Long-term degree training at Master’s, PhD and Career development
fellowship levels will be offered, with primary coursework to occur in Uganda at MakCHS. CNH will provide
both e-learning seminar and in-person immersive experience in the US to strengthen clinical trials capacity
and improve trainee’s knowledge of gender parity and sex- and gender considerations in health research.
Additionally, recruitment will target trainees from the regional centers to build National RHD capacity and
ensure at least 50% of our trainees are women. Short-term trainings, seminars, webinars and workshops
will be offered to degree and non-degree trainees to further strengthen institutional and national RHD-
research capacity and to identify promising candidates for degree programs. A Steering Committee and
the Training Advisory Committee (TAC) comprised of leading researchers with expertise in our objectives
will both offer expert advice to the Impact Directors to ensure success of the trainees and the overall
program by producing high-quality and locally relevant research. This success will translate into improving
guidelines and policies for RHD care in Uganda and the region, training the next generation of excellent
African researchers to address RHD prevention, early detection, and management.