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Building the Next Generation of Researchers in TB/HIV Diagnostics in Mali (B-NextGen)

Award Number: D43TW010350
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/09/2016
PERIOD OF PERFORMANCE END DATE: 03/31/2025

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Building the Next Generation of Researchers in TB/HIV Diagnostics in Mali (B-NextGen) - The overarching goal of this five year research training program, “Building the Next Generation of Researchers in HIV/TB Diagnostics in Mali” (B-NextGen), is to strengthen the scientific capacity at the Université des Sciences, Téchniques et des Téchnologies de Bamako (USTTB; University of Bamako) to conduct HIV research on the evolving HIV epidemic in Mali. B-NextGen will address four NIH high priority HIV research topics, including: 1) Reducing HIV incidence by improving screening and detection, treatment monitoring assays, and HIV drug resistance assays; 2) Diagnosing HIV-associated TB and non- tuberculous mycobacteria (NTM); 3) Reducing health disparities by developing testing technology that can function in underserved community settings; and 4) Training the LMIC workforce to conduct high priority HIV/AIDS research. Mali is a low-income country in Sub-Saharan West Africa where the incidence of mycobacterial infections, primarily tuberculosis (TB), remains high driven in a large part by the persistence of the HIV epidemic with TB being the main cause of dealth in HIV-infected adults and children. The World Health Organization (WHO) guidelines for managing HIV recommend rapid initiation of antiretroviral therapy (ART) and enhanced screening and diagnosis of TB, yet detection rates for HIV and TB, particularly in children, remain low in Mali as the current diagnostic and treatment monitoring tools are not adapted to the low- and middle-income (LMIC) environment. Northwestern University, Johns Hopkins University, and Stellenbosch University, have been successfully collaborating with USTTB for over a decade on several major projects focused on HIV and mycobacterial diseases including the predecessor to this renewal proposal “HIV and Mycobacterial Disease in Mali” (R Murphy, S Diallo, MPIs), which has been highly productive providing three “sandwich” PhD and ten MS degrees; > 200 short-term university diplomas; 25 peer-reviewed publications; and four major NIH grant awards. We will train the same number of researchers in this renewal proposal while we leverage this success to focus on outcome indicators of high public health importance. Our aims are: 1) Create a Department of Biomedical Engineering at the Mali National School of Engineering and establish a Master of Science in Biomedical Engineering focused on the development of devices and assays critical for the diagnosis and/or monitoring of HIV and mycobacterial diseases; 2) Develop an interdisciplinary core of research scientists from virology, applied molecular biology, immunology and microbiology to enhance the capacity to diagnose, treat, and monitor HIV and mycobacterial diseases; 3) Train clinical researchers and basic scientists in research methodology, validation and implementation applied principles, and career development activities essential for developing independent faculty; and 4) Develop the next generation of academic leaders in diagnostics, virology and mycobacteriology. Through this program, we will achieve the overall goal of training the next generation of investigators and leaders in diagnostics of HIV and mycobacterial diseases for adults and children in Mali.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$92,099 )
2026	2025	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO (USTTB)	HAMDALLAYE ACI 2000	BAMAKO				MLI	International Research and Research Training	000	10	3/26/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2026	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	001	9	8/25/2026	NON-COMPETING CONTINUATION	-$92,099
														Subtotal = -$92,099

Issue Date FY: 2025 ( Subtotal = $300,672 )
2025	2025	UNIVERSITE DES SCIENCES, DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO (USTTB)	HAMDALLAYE ACI 2000	BAMAKO				MLI	International Research and Research Training	001	10	8/20/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$300,672
2025	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	000	9	8/14/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $300,672

Issue Date FY: 2024 ( Subtotal = $298,963 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	000	9	4/11/2024	NON-COMPETING CONTINUATION	$298,963
														Subtotal = $298,963

Issue Date FY: 2023 ( Subtotal = $293,565 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	000	8	3/23/2023	NON-COMPETING CONTINUATION	$293,565
														Subtotal = $293,565

Issue Date FY: 2022 ( Subtotal = $302,673 )
2022	2022	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	004	7	4/1/2022	NON-COMPETING CONTINUATION	$302,673
2022	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	003	6	1/10/2022	COMPETING CONTINUATION	$32,911
2022	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	000	5	12/7/2021	NON-COMPETING CONTINUATION	-$32,911
2022	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	001	5	12/10/2021	NON-COMPETING CONTINUATION	$32,911
2022	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	002	5	1/10/2022	NON-COMPETING CONTINUATION	-$32,911
														Subtotal = $302,673

Issue Date FY: 2021 ( Subtotal = $307,993 )
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	003	6	8/30/2021	COMPETING CONTINUATION	$0
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	002	6	4/30/2021	COMPETING CONTINUATION	$0
2021	2021	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	001	6	4/19/2021	COMPETING CONTINUATION	$307,993
2021	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	000	5	4/15/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $307,993

Issue Date FY: 2020 ( Subtotal = $302,727 )
2020	2020	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	000	5	2/7/2020	NON-COMPETING CONTINUATION	$302,727
														Subtotal = $302,727

Issue Date FY: 2019 ( Subtotal = $303,095 )
2019	2019	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	000	4	2/20/2019	NON-COMPETING CONTINUATION	$303,095
														Subtotal = $303,095

Issue Date FY: 2018 ( Subtotal = $303,269 )
2018	2018	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	000	3	2/17/2018	NON-COMPETING CONTINUATION	$303,269
														Subtotal = $303,269

Issue Date FY: 2017 ( Subtotal = $303,893 )
2017	2017	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	000	2	2/24/2017	NON-COMPETING CONTINUATION	$303,893
														Subtotal = $303,893

Issue Date FY: 2016 ( Subtotal = $306,638 )
2016	2016	NORTHWESTERN UNIVERSITY	633 CLARK STREET	EVANSTON	IL	60208	COOK	USA	International Research and Research Training	000	1	4/9/2016	NEW	$306,638
														Subtotal = $306,638

Grand Total All Awards = $2,931,389

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Building the Next Generation of Researchers in TB/HIV Diagnostics in Mali (B-NextGen)

Award Number: D43TW010350

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/09/2016

PERIOD OF PERFORMANCE END DATE: 03/31/2025

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