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Building enteric infectious disease research capacity in India

Award Number: D43TW007392
ORGANIZATION: FOGARTY INTERNATIONAL CENTER
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/15/2005
PERIOD OF PERFORMANCE END DATE: 02/28/2022

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Building enteric infectious disease research capacity in India - DESCRIPTION (provided by applicant): This grant proposal "Building Enteric Infectious Disease Research Capacity in India" describes a training program in public health and infectious diseases, which includes interdisciplinary, translational training in in enteric infectious disease and the response to oral vaccines in developing countries. Enteric infectious diseases are the second major cause of post-neonatal mortality in under-5 children in developing countries, and cause both direct morbidity and sequelae in the form of growth faltering and possibly delayed cognitive development. The poor performance of oral vaccines in low-resource settings makes intervention challenging and a goal of this program is to focus training on inter-disciplinary studies on immunology and the role of gut microbiome in influencing the response to infection and immunization in India. Over the last nine years, a collaborative partnership between investigators at Tufts Medical Center/Tufts University School of Medicine (Tufts) and the Christian Medical College, Vellore (CMC) has established training with an initial focus on epidemiology, risk assessment and surveillance of enteric infections. Building on our knowledge, experience, and collaborative relationships, in this renewal application we will put greater emphasis on interventional clinical research, the enhancement of quantitative skills and in bio-informatics particularly related to the analysis and interpretation of metagenomic studies to develop a more translational approach during the next five years. We will expand the pool of potential trainees to all parts of India and the mentors to include faculty from the Centers for Disease Control and Prevention (CDC), Atlanta and Baylor College of Medicine (BCM), Houston. The goals of extending training in a variety of disciplines necessary to investigate gastrointestinal infections and immune response to oral vaccines with special emphasis on clinical research, vaccinology and bioinformatics, facilitating the transition of trainees to independent research and of working with the Indian government for prioritization of research and training and aid translation of research results into public health practice will be met by a tiered training program with three levels of trainees who will be trained in India and in the US, and who will carry out research projects in India. In each of 5 years, one long term and one intermediate term trainee will be supported with a basic training package, mentored research project development and conduct and continuing professional development. Long-term and intermediate term trainees will be either at the pre-doctoral or the post-doctoral level, with a focus on post-doctoral candidates as far as possible. In each year, one short-term (faculty level) trainee will be selected to attend either targeted training or a short course identified as being relevant to the research training goals of the program. Of a total of 15 trainees, we expect at least 2-3 doctoral degrees and at least 4 competitive research grants to be obtained by the trainees as post-doctoral trainees or faculty. Based on prior results, we expect an average of at least 10 publications annually to which trainees will contribute. Each long term trainee will be expected to have at least 2 first authored publications, and each intermediate term trainee will be expected to have one paper. In addition, the program faculty with work with the Department of Biotechnology's Clinical Service Development Agency to develop a credit based program-the Indian Clinical Researcher Development (InCReD) program which is intended as a new paradigm for providing research skills to 15-20 junior faculty annually at medical schools in India through a combination of distance learning and contact courses. The multi-disciplinary and complementary training, networking and career development support are expected to result in a sustainable research program with significantly increased skills and capacity for infectious disease research in India.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM, VELLORE DISTRICT	VELLORE	TAMIL NADU			IND	International Research and Research Training	000	15	3/15/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM VELLORE DISTRICT	VELLORE	TAMILNADU			IND	International Research and Research Training	000	15	6/11/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $263,714 )
2020	2020	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM VELLORE DISTRICT	VELLORE	TAMILNADU	632002		IND	International Research and Research Training	000	15	5/4/2020	NON-COMPETING CONTINUATION	$263,714
														Subtotal = $263,714

Issue Date FY: 2019 ( Subtotal = $228,809 )
2019	2019	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM VELLORE DISTRICT	VELLORE	TAMILNADU	632002		IND	International Research and Research Training	000	14	3/11/2019	NON-COMPETING CONTINUATION	$228,809
														Subtotal = $228,809

Issue Date FY: 2018 ( Subtotal = $256,044 )
2018	2018	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM VELLORE DISTRICT	VELLORE	TAMILNADU	632002		IND	International Research and Research Training	000	13	4/15/2018	NON-COMPETING CONTINUATION	$256,044
														Subtotal = $256,044

Issue Date FY: 2017 ( Subtotal = $232,561 )
2017	2017	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST, BAGAYAM VELLORE DISTRICT	VELLORE	TAMILNADU	632002		IND	International Research and Research Training	000	12	3/20/2017	NON-COMPETING CONTINUATION	$232,561
														Subtotal = $232,561

Issue Date FY: 2016 ( Subtotal = $239,085 )
2016	2016	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST	VELLORE				IND	International Research and Research Training	001	11	5/14/2016	COMPETING CONTINUATION	$239,085
2016	2014	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST	VELLORE		632002		IND	International Research and Research Training	000	10	5/13/2016	NON-COMPETING CONTINUATION	$0
														Subtotal = $239,085

Issue Date FY: 2014 ( Subtotal = $192,758 )
2014	2014	CHRISTIAN MEDICAL COLLEGE	THORAPADI POST	VELLORE				IND	International Research and Research Training	000	10	6/7/2014	NON-COMPETING CONTINUATION	$192,758
														Subtotal = $192,758

Issue Date FY: 2013 ( Subtotal = $188,784 )
2013	2013	CHRISTIAN MEDICAL COLLEGE	THORAPADI	VELLORE				IND	International Research and Research Training	000	9	6/8/2013	EXTENSION WITH OR WITHOUT FUNDS	$188,784
														Subtotal = $188,784

Issue Date FY: 2012 ( Subtotal = $198,720 )
2012	2012	CHRISTIAN MEDICAL COLLEGE	THORAPADI	VELLORE				IND	International Research and Research Training	000	8	5/12/2012	NON-COMPETING CONTINUATION	$198,720
														Subtotal = $198,720

Issue Date FY: 2011 ( Subtotal = $198,720 )
2011	2011	CHRISTIAN MEDICAL COLLEGE	THORAPADI	VELLORE				IND	International Research and Research Training	000	7	5/10/2011	NON-COMPETING CONTINUATION	$198,720
														Subtotal = $198,720

Issue Date FY: 2010 ( Subtotal = $213,208 )
2010	2010	CHRISTIAN MEDICAL COLLEGE	THORAPADI	VELLORE				IND	International Research and Research Training	001	6	8/13/2010	COMPETING CONTINUATION	$213,208
2010	2009	CHRISTIAN MEDICAL COLLEGE	POST OFFICE BOX 3	VELLORE		00000			International Research and Research Training	000	5	5/30/2010	NON-COMPETING CONTINUATION	$0
														Subtotal = $213,208

Issue Date FY: 2009 ( Subtotal = $133,315 )
2009	2009	CHRISTIAN MEDICAL COLLEGE	THORAPADI	VELLORE				IND	International Research and Research Training	000	5	3/19/2009	NON-COMPETING CONTINUATION	$133,315
														Subtotal = $133,315

Issue Date FY: 2008 ( Subtotal = $141,717 )
2008	2008	CHRISTIAN MEDICAL COLLEGE	POST OFFICE BOX 3	VELLORE		00000			International Research and Research Training	000	4	4/17/2008	NON-COMPETING CONTINUATION	$141,717
														Subtotal = $141,717

Issue Date FY: 2007 ( Subtotal = $133,315 )
2007	2007	CHRISTIAN MEDICAL COLLEGE	POST OFFICE BOX 3	VELLORE		00000			International Research and Research Training	000	3	4/2/2007	NON-COMPETING CONTINUATION	$133,315
														Subtotal = $133,315

Issue Date FY: 2006 ( Subtotal = $141,824 )
2006	2006	CHRISTIAN MEDICAL COLLEGE	POST OFFICE BOX 3	VELLORE		00000			International Research and Research Training	000	2	4/10/2006	NON-COMPETING CONTINUATION	$141,824
														Subtotal = $141,824

Issue Date FY: 2005 ( Subtotal = $148,000 )
2005	2005	CHRISTIAN MEDICAL COLLEGE	POST OFFICE BOX 3	VELLORE		00000			International Research and Research Training	000	1	8/15/2005	NEW	$148,000
														Subtotal = $148,000

Grand Total All Awards = $2,910,574

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Building enteric infectious disease research capacity in India

Award Number: D43TW007392

ORGANIZATION: FOGARTY INTERNATIONAL CENTER

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/15/2005

PERIOD OF PERFORMANCE END DATE: 02/28/2022

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