Community Project Funding/Congressionally Directed Spending - Construction - The goal of this HRSA proposal is to fit-out existing leased, open shell space in Frazier Rehab Institute’s 14th floor to house the Spinal Cord Injury Neuromodulation and Translational Recovery Institute. This effort, based on sustainable design and construction, will expand the University of Louisville’s ability to provide vital care, rehabilitation, and cutting-edge research to transform healthcare for children with spinal cord injury (SCI). In 2001, recognizing a critical need, the Kentucky Spinal Cord Injury Research Center (KSCIRC) was established to provide acute clinical neurologic care to treat adults with SCI based on rehabilitation research. In 2005, KSCIRC expanded its research and clinical services to include restorative-based interventions: activity-based locomotor training and neuromuscular electrical stimulation. These clinical practices are now integral to improving respiratory health and walking recovery for persons with SCI. Through seminal research, using state-of-the-art neuromodulation strategies including epidural stimulation, KSCIRC investigators have demonstrated that completely paralyzed individuals can achieve significant gains in health, mobility, and quality of life. In 2014, the University of Louisville’s (UofL) Kosair for Kids Center for Pediatric NeuroRecovery was launched expanding KSCIRC’s mission to children with SCI ages 15 months to 18 years. Children and their families from across the U.S. and world seek our cutting-edge rehabilitation therapies and participate in research designed to find solutions to paralysis and significantly improve health. Children, often viewed as having little hope for recovery, are achieving novel and historically unexpected gains in their ability to sit up, grasp, stand, walk, hold their head up, and even breathe better while decreasing threats to their health. Today, KSCIRC is internationally recognized as leaders in neuromodulation targeting recovery, serving daily 14 children with SCIs including those on ventilators, the very young and those considered medically complex and fragile. The Center for Pediatric NeuroRecovery is uniquely poised to provide transformative SCI care. Traditionally, SCI has been treated via ‘silos’ whereby medical and rehabilitation specialists narrowly ‘manage’ a single physiological system as a disconnected entity. Transformative care is embodied by clinicians and research scientists working side-by-side using KSCIRC’s SCI care model for evaluating the whole body. Disease is prevented through restorative, scientific-based treatments that repair or augment residual and integrated sensorimotor and autonomic systems. Our teams effectively deliver care across physiological systems by driving networks involved in activation and/or repair of critical integrated sensorimotor and autonomic systems. The daily partnership of clinicians and researchers in clinical care and bi-directional research effectively fast-tracks scientific evidence into practice. Capitalizing on our integrated, wholistic approach to rehabilitation and healthcare, patients achieve a higher level of recovery, health, and quality of life, while clinical and research partners accelerate translation of scientific-based strategies to practices that effectively improve outcomes. By Sept. 2026, this project will house the integrated clinic and research arms of the Spinal Cord Injury Neuromodulation and Translational Recovery Institute, its Pediatric NeuroRecovery program, on the 14th floor of Frazier Rehab Institute. The space will accommodate 24 children per day, doubling the number of children served. Co-designed with the SCI community, common areas will serve patients of all ages and their families while providing access to private consultations, networking events, and scientific and clinical materials for education.