This project’s goal is to develop an intervention to enable return-to-work by employees disabled by brain fog and other cognitive impairments due to Post-Acute Sequelae of COVID-19 (PASC). PASC, popularly known as long COVID, is estimated to have produced persistent cognitive sequelae in 2 million in the US alone to date. To accomplish the goal, our research group will partner with the state vocational rehabilitation (VR) agency, employers, and a stakeholder Advisory Board. Preliminary data indicate that Constraint-Induced Cognitive Therapy (CICT), a new approach to cognitive rehabilitation that emphasizes transfer of improvements in cognition to everyday function, has high promise for ameliorating PASC cognitive sequalae. Our objectives are to: 1) refocus CICT and combine it with VR to target job return; 2) assess the feasibility of the combination, CICT+VR, that emerges, 3) evaluate the efficacy, on a preliminary basis, of CICT+VR for promoting job return relative to (a) extant cognitive rehabilitation plus VR and (b) VR alone; and 4) assess the feasibility of a study design and set of outcomes for an appropriately-powered efficacy trial, which would be a logical step if the proposed work has positive findings. Anticipated outcomes include: 1) a well-specified protocol for rehabilitation of employees with cognitive impairment due to PASC; 2) data on the feasibility of the protocol and of a study design for evaluating its effectiveness; and 3) preliminary data on its efficacy. Expected products are several publications and presentations, a manual of procedures, and a network of researchers and stakeholders to support further work on this new approach. The primary outcome domain will be employment.