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 | Issue Date FY: 2024 ( Subtotal = $3,331,304 ) |
| | 2024 | 2024 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01DK132355 | Circulating miRNAs and prediction of beta-cell treatment response: The Restoring Insulin Secretion Study | 000 | 3 | NIH | 2/12/2024 | $432,974 |
| | 2024 | 2024 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R61AG080614 | Tai Chi Practice and Sleep-Active Glymphatic Function | 000 | 2 | NIH | 12/12/2023 | $423,374 |
| | 2024 | 2024 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01DK134502 | Effects of Cholesterol in Pancreatic Islets | 000 | 2 | NIH | 4/2/2024 | $387,718 |
| | 2024 | 2024 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01CA279220 | SArcopenia in Men with Prostate Cancer undergoing ADT (SAP-ADT) | 000 | 1 | NIH | 1/12/2024 | $651,680 |
| | 2024 | 2024 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01AG075338 | Role of Astrocyte EAAT2/GLT1 Failure in Alzheimer's Disease Pathogenesis | 000 | 3 | NIH | 1/18/2024 | $647,339 |
| | 2024 | 2024 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01NS119897 | Investigating the role of lipid metabolism in protein aggregation and neurodegenerative disease progression | 000 | 4 | NIH | 11/20/2023 | $318,592 |
| | 2024 | 2024 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01AG066211 | Protection from pathological tau by activation of the ER unfolded protein response | 000 | 5 | NIH | 1/8/2024 | $510,988 |
| | 2024 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01DA052618 | Microglia and Opioid Withdrawal: Mechanisms of Negative Reinforcement | 000 | 3 | NIH | 2/8/2024 | $0 |
| | 2024 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01AG084680 | Formation of Tau RNA Complexes disrupts tau function and drives tau neuropathology | 000 | 1 | NIH | 10/11/2023 | $0 |
| | 2024 | 2022 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R21MH123840 | User-centered Design and Evaluation of a Virtual Human Patient to Improve Safety Planning Skills | 000 | 2 | NIH | 4/12/2024 | $0 |
| | 2024 | 2021 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | U01DK048413 | 8/22 Limited Competition for the Continuation of the Diabetes Prevention Program Outcomes Study (DPPOS) - Clinical Center | 000 | 28 | NIH | 10/27/2023 | -$1,200 |
| | 2024 | 2021 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | U01DK048413 | 8/22 Limited Competition for the Continuation of the Diabetes Prevention Program Outcomes Study (DPPOS) - Clinical Center | 000 | 28 | NIH | 10/27/2023 | -$1 |
| | 2024 | 2021 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01AG054456 | Defining the role of age-related glymphatic pathway impairment in amyloid beta plaque deposition | 000 | 6 | NIH | 12/7/2023 | -$1,439 |
| | 2024 | 2020 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | RF1AG059088 | Effects of apoE Isoform, Sex and Diet on Insulin Regulation in Brain | 000 | 1 | NIH | 2/20/2024 | -$37,977 |
| | 2024 | 2020 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R21AG065928 | Characterization of a human in vitro blood-brain barrier model to study the effects of systemic aging on responses to Alzheimer's disease effectors | 000 | 1 | NIH | 12/11/2023 | -$743 |
|
| Issue Date FY: 2023 ( Subtotal = $11,910,923 ) (Continued on the next page) |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01AG061558 | Improving cancer-related fatigue, sexual dysfunction and quality of life in older men with cancer and androgen deficiency | 000 | 4 | NIH | 6/6/2023 | $673,710 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | RF1AG078335 | Targeting MSUT2 with small molecules to ameliorate pathological tau | 000 | 1 | NIH | 8/16/2023 | $2,181,250 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01DA052618 | Microglia and Opioid Withdrawal: Mechanisms of Negative Reinforcement | 000 | 3 | NIH | 7/17/2023 | $383,910 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01NS129573 | Role of Sleep Disruption after mTBI as a Driver of Chronic Post-traumatic Headache | 000 | 1 | NIH | 6/20/2023 | $611,529 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | RF1AG078374 | SPOP drives neurodegenerative tauopathy | 000 | 1 | NIH | 8/18/2023 | $1,823,353 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R01DK134502 | Effects of Cholesterol in Pancreatic Islets | 000 | 1 | NIH | 12/28/2022 | $417,336 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R61AG080614 | Tai Chi Practice and Sleep-Active Glymphatic Function | 001 | 1 | NIH | 3/28/2023 | $0 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R61AG080614 | Tai Chi Practice and Sleep-Active Glymphatic Function | 000 | 1 | NIH | 12/15/2022 | $493,814 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R01AG066211 | Protection from pathological tau by activation of the ER unfolded protein response | 000 | 4 | NIH | 2/1/2023 | $520,000 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R01DK132355 | Circulating miRNAs and prediction of beta-cell treatment response: The Restoring Insulin Secretion Study | 000 | 2 | NIH | 2/8/2023 | $481,081 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R01CA239208 | Improving Patient-Important Outcomes with Testosterone Replacement in Hypogonadal Men with a Prior History of Cancer | 000 | 4 | NIH | 5/17/2023 | $125,176 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01AR076475 | Characterizing and Restoring Joint Motion in Patients with Hallux Rigidus | 000 | 4 | NIH | 8/11/2023 | $282,895 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R01AG075338 | Role of Astrocyte EAAT2/GLT1 Failure in Alzheimer's Disease Pathogenesis | 000 | 2 | NIH | 1/18/2023 | $726,367 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01DK133317 | Role of the Renin-Angiotensin System in Glucose Homeostasis | 000 | 2 | NIH | 6/6/2023 | $390,455 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R33AG064271 | Use of wearable sensors to improve the early diagnosis of DLB | 001 | 4 | NIH | 8/1/2023 | $703,884 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R21NS118476 | Investigating a neuroprotective role of GBA in astrocytes | 000 | 2 | NIH | 1/26/2023 | $170,250 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01AR078487 | Helping patients and physicians choose the appropriate surgery for end stage hallux rigidus | 000 | 3 | NIH | 6/14/2023 | $119,856 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R01AG066729 | TDP-43 in Alzheimer's disease | 000 | 3 | NIH | 5/22/2023 | $530,161 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R01NS119897 | Investigating the role of lipid metabolism in protein aggregation and neurodegenerative disease progression | 001 | 3 | NIH | 1/31/2023 | $41,664 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R01NS119897 | Investigating the role of lipid metabolism in protein aggregation and neurodegenerative disease progression | 000 | 3 | NIH | 12/14/2022 | $374,996 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01CA243907 | Improving the Reach and Effectiveness of Smoking Cessation Services Targeted to Veterans Living with HIV | 000 | 5 | NIH | 9/7/2023 | $250,000 |
| | 2023 | 2023 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01AG084680 | Formation of Tau RNA Complexes disrupts tau function and drives tau neuropathology | 000 | 1 | NIH | 9/26/2023 | $638,837 |
| | 2023 | 2022 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R33AG064271 | Use of wearable sensors to improve the early diagnosis of DLB | 000 | 3 | NIH | 4/4/2023 | $39,245 |
| | 2023 | 2021 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | U01HL142103 | AdvanCing High quality COPD care for people with immune dysfunction by implementing Evidence-based management through proactive E-consults (ACHIEVE) | 000 | 4 | NIH | 3/31/2023 | $0 |
| | 2023 | 2021 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | U01HL142103 | AdvanCing High quality COPD care for people with immune dysfunction by implementing Evidence-based management through proactive E-consults (ACHIEVE) | 001 | 4 | NIH | 4/18/2023 | $0 |
| | 2023 | 2021 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | R01DK115976 | Role of Brown Adipose Tissue Thermogenesis in Oxytocin-Elicited Weight Loss | 000 | 4 | NIH | 11/10/2022 | $0 |
| | 2023 | 2020 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY # 151F | SEATTLE | WA | 98108-1532 | KING | USA | RF1AG059088 | Effects of apoE Isoform, Sex and Diet on Insulin Regulation in Brain | 001 | 1 | NIH | 10/21/2022 | $0 |
| | 2023 | 2020 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R21AG064271 | Use of wearable sensors to improve the early diagnosis of DLB | 000 | 2 | NIH | 4/4/2023 | -$39,245 |
| | 2023 | 2020 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01DK088082 | Islet Endothelial Dysfunction in Diabetes | 000 | 9 | NIH | 9/27/2023 | $0 |
| | 2023 | 2019 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R21ES029657 | Ozone-induced Depression, Cognitive Impairment, and Serum Amyloid A: A Lung-Liver-Brain Axis | 000 | 2 | NIH | 11/23/2022 | $0 |
| | 2023 | 2019 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R21HD095516 | The Evaluation and Redesign of Transmetatarsal Prosthetics to Reduce Peak Plantar Pressures. | 000 | 2 | NIH | 7/27/2023 | -$17,879 |
| | 2023 | 2018 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | R01CA196692 | Does Screening for HCC in Cirrhotic Patients Reduce HCC-related Mortality? | 000 | 4 | NIH | 5/9/2023 | -$11,721 |
| | 2023 | 2018 | SEATTLE INSTITUTE FOR BIOMEDICAL AND CLINICAL RESEARCH | 1660 S COLUMBIAN WAY | SEATTLE | WA | 98108-1532 | KING | USA | U01HL128868 | Health through Obesity care for PatiEnts with COPD (HOPE) | 000 | 4 | NIH | 11/21/2022 | -$1 |
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