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 | Issue Date FY: 2024 ( Subtotal = $15,774,375 ) (Continued on the next page) |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA237200 | Exploring the role of estrogen receptor beta in progression and metastasis ofInflammatory breast cancer | 000 | 6 | NIH | 12/4/2023 | $332,488 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R61CA278458 | A multiplexed high-throughput platform to report pharmacologic alteration of cancer stem cell membrane potential and cell cycle state | 000 | 1 | NIH | 3/20/2024 | $240,484 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R21NS127229 | Patterned optogenetic neuromodulation to reprogram glioma stem cells | 000 | 1 | NIH | 1/8/2024 | $444,125 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA288403 | Decoupling acute toxicities and antitumor efficacy in adoptive cell therapy | 000 | 1 | NIH | 4/18/2024 | $600,313 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01AI179616 | Modulation of chromatin dynamics to promote transplant survival | 000 | 1 | NIH | 12/6/2023 | $581,920 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA280746 | Targeting phenethyl isothiocyanate to mitochondria in lung carcinogenesis | 000 | 1 | NIH | 2/2/2024 | $645,107 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R56AI132492 | Impact of Irreversible T Cell Dysfunction on Transplant Outcomes | 000 | 6 | NIH | 1/12/2024 | $290,700 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA285209 | Tumor-specific CD8+ Tc9 cells activate host CD4+ T cells to control antigen-lost tumors | 000 | 1 | NIH | 12/21/2023 | $489,857 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA278911 | Induction of autosis to overcome resistance in adoptive cell therapy for solid tumors | 001 | 2 | NIH | 4/17/2024 | $28,413 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA278911 | Induction of autosis to overcome resistance in adoptive cell therapy for solid tumors | 000 | 2 | NIH | 3/6/2024 | $511,452 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01AI176558 | Regulation of Cell Death in HIV Reservoirs | 000 | 2 | NIH | 2/16/2024 | $534,415 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01HL163535 | Human Atherogenesis with Underlying Dysfunctional HDL-Free Cholesterol | 000 | 2 | NIH | 2/2/2024 | $676,248 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01HL168277 | Cardiac Autonomic Activation In Atrial Fibrillation Triggers And Substrate | 000 | 2 | NIH | 2/12/2024 | $722,692 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01AI167659 | Long-acting multi prevention implant for 2-year contraception and HIV PrEP | 000 | 2 | NIH | 4/17/2024 | $816,407 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01AG077685 | Central and peripheral immune cross-talk in Alzheimer's disease and their modulation by a novel immunotherapy | 000 | 2 | NIH | 12/28/2023 | $586,387 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01DK134340 | A randomized, sham-controlled clinical trial evaluating individualized neuromodulation of cortical regions involved in neurogenic overactive bladder in Multiple Sclerosis | 000 | 2 | NIH | 12/18/2023 | $312,018 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R21AI175821 | Emergence of TonB-dependent receptor mediated cefiderocol resistance among multidrug-resistant (MDR) Pseudomonas aeruginosa clinical isolates. | 000 | 2 | NIH | 12/14/2023 | $266,206 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA269835 | Mechanisms of STING in malignant progression and therapy of CLL. | 000 | 2 | NIH | 2/6/2024 | $442,928 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA268340 | XBP1 Inhibition and STING activation for the treatment of cancer | 000 | 3 | NIH | 3/14/2024 | $517,036 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01HL158703 | Mechanisms driving cardiac dysfunction in Autosomal Dominant Polycystic Kidney Disease | 000 | 3 | NIH | 3/22/2024 | $403,750 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01NS121405 | S100A4 mediated immune suppression in GBM | 000 | 4 | NIH | 1/24/2024 | $394,788 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA253865 | Nanoparticle delivery of miRNA-based therapeutics to overcome clinical challenges in triple negative breast cancer | 000 | 4 | NIH | 2/29/2024 | $358,221 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01ES031511 | Systems-wide analysis of oxidative stress-responsive m6A epitranscriptome | 000 | 4 | NIH | 3/28/2024 | $402,308 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA238727 | Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumors | 000 | 5 | NIH | 2/6/2024 | $332,488 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01AI146048 | Molecular mechanism of streptococcal adaptation to host nutritional defenses | 000 | 5 | NIH | 3/13/2024 | $224,575 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | U01CA244107 | Biophysical roles of pre-metastatic niche evolution on transport of circulating tumor cells | 000 | 5 | NIH | 4/15/2024 | $507,540 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01NS115748 | Myelin Junction Therapy in Peripheral Neuropathies | 000 | 5 | NIH | 12/28/2023 | $344,541 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA288884 | Functional roles of mTOR in tumor persistence | 000 | 1 | NIH | 4/4/2024 | $401,087 |
| | 2024 | 2024 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01AI106200 | Control of dysfunctional Tregs | 000 | 9 | NIH | 1/25/2024 | $436,049 |
| | 2024 | 2023 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R56AG080920 | Microbiota-targeted approaches to resolve dysbiosis-induced AD neuropathology following brain injury. | 000 | 1 | NIH | 10/24/2023 | $0 |
| | 2024 | 2023 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R21AR083189 | In situ and real-time readout of nuclear mechanotransduction via single cell mechanics and site-specific fluorescence reporting | 000 | 1 | NIH | 11/16/2023 | -$375,092 |
| | 2024 | 2023 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R21AR083189 | In situ and real-time readout of nuclear mechanotransduction via single cell mechanics and site-specific fluorescence reporting | 001 | 1 | NIH | 12/4/2023 | $375,092 |
| | 2024 | 2023 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | U54CA274375 | The stromal microenvironment as a co-organizer of bladder carcinogenesis and progression | 002 | 2 | NIH | 1/26/2024 | $0 |
| | 2024 | 2023 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | U54CA274375 | The stromal microenvironment as a co-organizer of bladder carcinogenesis and progression | 001 | 2 | NIH | 12/5/2023 | $1,745,043 |
| | 2024 | 2023 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01NS124813 | Pathogenesis in Segmental Demyelination | 001 | 2 | NIH | 2/6/2024 | $385,000 |
| | 2024 | 2023 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01AI165372 | Ultra-long Acting Transcutaneously Refillable Islatravir Nanofluidic Implant for HIV Pre-Exposure | 000 | 2 | NIH | 11/14/2023 | $0 |
| | 2024 | 2023 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA175397 | Distinct Tumor and Metastatic Collagen Microenvironments: Divergent Targeting Approaches | 000 | 9 | NIH | 12/5/2023 | $0 |
| | 2024 | 2022 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R34NS128894 | Neural coding of natural stimuli in freely moving macaque | 001 | 2 | NIH | 4/8/2024 | $466,031 |
| | 2024 | 2022 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01AI132492 | IRF4-dependent T-cell effector programs in governing transplant outcomes | 000 | 5 | NIH | 1/5/2024 | $0 |
| | 2024 | 2022 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | K08AI135093 | Role of YxdJK and DAK in the Enterococcal Envelope Stress Response | 000 | 6 | NIH | 2/16/2024 | -$45,677 |
| | 2024 | 2022 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA224304 | Self-assembled multifunctional aptamer-complex biomaterial for precision medicine | 000 | 5 | NIH | 1/4/2024 | $0 |
| | 2024 | 2022 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | U01NS104326 | Clinical Trial Readiness for SCA1 and SCA3 | 000 | 5 | NIH | 1/8/2024 | $0 |
| | 2024 | 2022 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA205633 | Inhibition of Oral Tumorigenesis by Antitumor B | 000 | 6 | NIH | 11/8/2023 | $0 |
| | 2024 | 2022 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA204191 | LILRB modulates tumor microenvironment and promotes tumor progression | 000 | 6 | NIH | 12/11/2023 | $0 |
| | 2024 | 2022 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01HL103827 | Targeting Notch2 in Hematopoietic Cell Therapy | 001 | 10 | NIH | 11/8/2023 | $590,982 |
| | 2024 | 2021 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R03AG064266 | A new conditional TDP?NLS knock-in mouse model generated using CRISPR/Cas9 technology to study the linkage of TDP-43 pathology to motor and cognitive defects in ALS, FTD and ADRD | 000 | 2 | NIH | 12/4/2023 | $0 |
| | 2024 | 2021 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01HL133254 | Role of S-nitrosylation in Transdifferentiation | 000 | 4 | NIH | 10/13/2023 | -$49,544 |
| | 2024 | 2021 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01GM127558 | A nanofluidic platform for tunable drug delivery | 000 | 4 | NIH | 11/30/2023 | $0 |
| | 2024 | 2021 | METHODIST HOSPITAL, THE | 6670 BERTNER AVE | HOUSTON | TX | 77030-2602 | HARRIS | USA | R01CA211861 | The Germ Cell Gene TDRD1 as a Novel Prostate Cancer Biomarker | 000 | 5 | NIH | 2/5/2024 | -$133,142 |
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