New York University Clinical and Translational Science Hub - The New York University (NYU) Clinical and Translational Science Institute (CTSI) is a vibrant public–private collaboration between NYU Langone Health (NYULH), the NYU Grossman School of Medicine and NYU Grossman Long Island School of Medicine; the Family Health Centers at NYULH, our Community and Patient Advisory Boards, and all other NYU schools and colleges. Moreover, our partnerships with NYC Health and Hospitals, the nation’s largest municipal healthcare system; the Nathan Kline Institute, a psychiatric research institute; Kingsborough Community College, and >150 additional community partners allow us to reach all populations across New York City. Our focus over the next 7 years is to emphasize collaboration as a fundamental approach to advancing clinical translational science (CTS) while overcoming barriers, bridging communities, fostering a well-rounded science workforce, and continuously evaluating and improving the quality and impact of our research. We will partner with communities to bring research to where people live and promote practice and policy through five overarching aims. Aim 1: Enhance Community-Engaged Research. We will leverage our unique strengths collaborating with patient, community, and multisector partners to establish innovative research programs and practice-based learning health systems. Aim 2: Democratize Health Informatics (HI) Resources. We will foster a collaborative environment to develop, implement, and disseminate innovative HI resources that enhance the quality, safety, efficiency, and reproducibility of clinical translational research (CTR) and CTS. Aim 3: Develop a Well-Rounded Workforce to Advance CTS. We will create collaborative learning initiatives that involve research faculty, staff, clinicians, students, and community members. Aim 4: Catalyze Regional and National Collaborations to Accelerate CTS Research. We will promote and facilitate partnerships at regional and national levels to accelerate CTS research through interdisciplinary team science and knowledge sharing. Aim 5: Advance Clinical Trials through Collaborative Partnerships. We will develop and implement operational innovations to accelerate start-up and completion of clinical trials, while elevating their quality, safety, effectiveness, and impact. These goals capitalize on our major strengths, emphasizing collaborations with community and multisector partners, interdisciplinary engagement across NYU and its 11 colleges and schools, and active participation in the CTSA consortium. For the next 7 years, we envision a future in which scientific breakthroughs more swiftly transition from bench to the bedside and into our communities so every individual receives access to innovative healthcare solutions.