Johns Hopkins Institute for Clinical and Translational Research - The Johns Hopkins Institute for Clinical and Translational Research (ICTR) has been a productive, innovative and impactful organization in transforming how clinical and translational research is conducted. Enhancing collaborative research teams, advancing informatics, promoting new methodologies, providing access to regulatory support, and bringing researchers and the community closer together as true partners in discovery have all made translational research more successful. Over the next seven years, the Johns Hopkins ICTR will continue its current research community as a comprehensive regional hub that includes partners – the University of Maryland Baltimore (UMB), Hugo W. Moser Research Institute at Kennedy Krieger Inc. (KKI) and Morgan State University (MSU). We will continue to work with collaborator Kaiser Permanente Mid-Atlantic States (KPMAS), and add the University of Maryland Baltimore County (UMBC) and the University of Maryland College Park (UMCP) as new collaborators. These entities bring complementary expertise and connections to distinct populations in the State of Maryland, with emphasis on underserved rural and urban areas. Together, we have an opportunity to conduct high quality innovative research, and rapidly implement and integrate and disseminate findings that impact the health of our state and region. Building on our extensive connections with community groups, we will continue joint governance with bidirectional communication and participation on key ICTR committees. We will focus on improving methodologic and operational support for research teams conducting randomized clinical trials so that the impact of these trials is enhanced. The ICTR provides a model for training investigators to work in multidisciplinary teams with experienced mentors using the most rigorous methodologies. Based on recent events we have added new programs on Research in Response to National Emergencies and Dissemination and Implementation Core. Trust in research organizations has been decreasing. Our research project is to evaluate whether return of aggregate study results can increase satisfaction with research and trust in research. The ICTR is poised to leverage our current services to benefit new partners who have extensive responsibility for the conduct of research and health care delivery in Maryland. Working together, we expect to have a measurable impact on translational research in Maryland.