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Cardiovascular Cell Therapy Research Network

Award Number: UM1HL087365
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2007
PERIOD OF PERFORMANCE END DATE: 02/28/2021

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Cardiovascular Cell Therapy Research Network - DESCRIPTION (provided by applicant): The Cardiovascular Cell Therapy Research Network (CCTRN) I worked collaboratively to achieve its goal of successfully conducting 3 clinical trials of cell therapy: FOCUS, TIME, and LateTIME. As a Regional Clinical Center (RCC) for CCTRN I, the Texas Heart Institute (THI) contributed significantly to the development, implementation, and enrollment of the 3 trials, CCTRN I adopted our protocol, FOCUS, as one of its trials, and we shared our extensive experience in conducting clinical trials in patients with chronic heart disease as well as our expertise in performing NOGA mapping and injection procedures. THI met 100% of our recruitment goals in the CCTRN I (top in enrollment for FOCUS), aided by our innovative, multimedia campaign for patient recruitment. THI contributed significantly to the CCTRN's satellite strategy for enrollment by recruiting the first VA hospital to the network. Finally, CCTR I overwhelmingly selected our bridging protocol (cell therapy in patients with intermittent claudication) to be implemented in the latter support period. In this application, THI enthusiastically seeks to continue serving as an RCC for CCTRN II, under the leadership of James T. Willerson, MD, President and Medical Director of THI, as PI, and Emerson C. Perin, MD, PhD, Director of Research in Cardiovascular Medicine and the Stem Cell Center at THI, as co-PI. In addition to the VA satellite, THI proposes to add 2 large, strategically located satellit centers to CCTRN II-the University of Texas Southwestern Medical Center in Dallas and the John Ochsner Heart and Vascular Institute in New Orleans. We are also submitting applications for the Clinical Research Skills Development Programs. The aim of our first research protocol is to perform the first head-to-head comparison of the effects of 3 different cell types on cardiac function and perfusion in a randomized, controlled clinical trial in patients with chronic heart disease, with the inclusion of a small tracking arm to study cell fate after delivery into the hear. The aim of our second protocol is to conduct the first randomized, double-blind, controlled clinical trial of the safety and efficacy of stem cell therapy in patients who have the most common presentation of myocardial infarction, non-ST segment elevation myocardial infarction.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $586,552 )
2022	2018	TEXAS HEART INSTITUTE	6770 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	002	12	6/27/2022	NON-COMPETING CONTINUATION	-$320,872
2022	2018	TEXAS HEART INSTITUTE	6770 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	001	12	12/22/2021	NON-COMPETING CONTINUATION	$669,043
2022	2017	TEXAS HEART INSTITUTE	6770 BERTNER AVE	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	11	12/22/2021	NON-COMPETING CONTINUATION	$238,381
														Subtotal = $586,552

Issue Date FY: 2021 ( Subtotal = -$907,424 )
2021	2018	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	002	12	8/9/2021	NON-COMPETING CONTINUATION	-$669,043
2021	2018	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	12	3/11/2021	NON-COMPETING CONTINUATION	$0
2021	2017	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	001	11	8/9/2021	NON-COMPETING CONTINUATION	-$238,381
														Subtotal = -$907,424

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2018	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	12	2/21/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2018	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	12	6/20/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $669,043 )
2018	2018	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	12	4/7/2018	NON-COMPETING CONTINUATION	$669,043
														Subtotal = $669,043

Issue Date FY: 2017 ( Subtotal = $675,419 )
2017	2017	TEXAS HEART INSTITUTE	6770 BERTNER AVE MC3 117	HOUSTON	TX	77030	HARRIS	USA	Cardiovascular Diseases Research	000	11	2/10/2017	NON-COMPETING CONTINUATION	$675,419
														Subtotal = $675,419

Issue Date FY: 2016 ( Subtotal = $784,438 )
2016	2016	TEXAS HEART INSTITUTE	P.O. BOX 20345	HOUSTON	TX	77225	HARRIS	USA	Cardiovascular Diseases Research	001	10	7/28/2016	SUPPLEMENT FOR EXPANSION	$100,000
2016	2016	TEXAS HEART INSTITUTE	P.O. BOX 20345	HOUSTON	TX	77225	HARRIS	USA	Cardiovascular Diseases Research	000	10	2/22/2016	EXTENSION WITH OR WITHOUT FUNDS	$684,438
														Subtotal = $784,438

Issue Date FY: 2015 ( Subtotal = $260,542 )
2015	2015	TEXAS HEART INSTITUTE	P.O. BOX 20345	HOUSTON	TX	77225	HARRIS	USA	Cardiovascular Diseases Research	000	9	3/23/2015	NON-COMPETING CONTINUATION	$260,542
														Subtotal = $260,542

Issue Date FY: 2014 ( Subtotal = $791,909 )
2014	2014	TEXAS HEART INSTITUTE	P.O. BOX 20345	HOUSTON	TX	77225	HARRIS	USA	Cardiovascular Diseases Research	000	8	2/18/2014	NON-COMPETING CONTINUATION	$727,264
2014	2014	TEXAS HEART INSTITUTE	P.O. BOX 20345	HOUSTON	TX	77225	HARRIS	USA	Cardiovascular Diseases Research	001	8	3/3/2014	NON-COMPETING CONTINUATION	$64,645
														Subtotal = $791,909

Issue Date FY: 2013 ( Subtotal = $776,390 )
2013	2013	TEXAS HEART INSTITUTE	P.O. BOX 20345	HOUSTON	TX	77225	HARRIS	USA	Cardiovascular Diseases Research	001	7	6/26/2013	NON-COMPETING CONTINUATION	$42,409
2013	2013	TEXAS HEART INSTITUTE	P.O. BOX 20345	HOUSTON	TX	77225	HARRIS	USA	Cardiovascular Diseases Research	000	7	2/20/2013	NON-COMPETING CONTINUATION	$733,981
														Subtotal = $776,390

Issue Date FY: 2012 ( Subtotal = $863,317 )
2012	2012	TEXAS HEART INSTITUTE	P.O. BOX 20345	HOUSTON	TX	77225	HARRIS	USA	Cardiovascular Diseases Research	000	6	3/13/2012	COMPETING CONTINUATION	$1,105,035
2012	2012	TEXAS HEART INSTITUTE	P.O. BOX 20345	HOUSTON	TX	77225	HARRIS	USA	Cardiovascular Diseases Research	001	6	7/26/2012	COMPETING CONTINUATION	-$241,718
														Subtotal = $863,317

Grand Total All Awards = $4,500,186

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Cardiovascular Cell Therapy Research Network

Award Number: UM1HL087365

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2007

PERIOD OF PERFORMANCE END DATE: 02/28/2021

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