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Mouse Phenotyping Informatics Infrastructure - Data acquisition, integration, analysis and translation of high throughput mammalian phenotyping data.

Award Number: UM1HG006370
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2011
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Mouse Phenotyping Informatics Infrastructure - Data acquisition, integration, analysis and translation of high throughput mammalian phenotyping data. - PROJECT SUMMARY The International Mouse Phenotyping Project (MPI2) is a critical resource for biomedical research providing novel gene-phenotype associations for genes with little or no known function, supplying strains for thousands of mechanistic studies and delivering integration with genomic, phenomic and human disease-relevant information providing improved understanding into the underlying causes of rare and common disease. The MPI2 Consortium will continue to support project data generating partners by providing data acquisition, analysis, visualisation, quality control and integration of this valuable dataset ensuring it is robust and highly accessed. Specifically: • Develop and enhance standardized protocols for phenotyping tests and enhanced data upload and quality control processes ensuring tracking of consortium-wide progress of strain production and data generation and provision of FAIR quality controlled data for community use • Deliver statistical analysis and annotation pipelines extended to improve precision and recall of phenotypes of the growing dataset and image analysis techniques will extract new knowledge from >500,000 images. Phenotype comparisons to identify candidate disease models will be enhanced by including new disease populations and more extensive semantic mappings with human phenotype ontologies • Ensure rapid statistical analysis for newly acquired and quality controlled data enabling users to access new strains and knowledge about them quickly from the project’s web portal. • Enhance the project’s web portal for all users, new features for clinical user groups including visualisation tools with presentation improved for disease researchers and complex queries enabling deeper interrogation of phenotypes of interest for disease • Deliver a suite of training materials enabling learning journeys for diverse user groups • Deliver a communication and outreach strategy ensuring the project’s visibility increases and tracking new knowledge generated by the community using IMPC’s lines and data


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$109,999 )
2025	2024	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	003	13	3/24/2025	NON-COMPETING CONTINUATION	$0
2025	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Trans-NIH Research Support	002	10	10/1/2024	SUPPLEMENT FOR EXPANSION	-$33,000
2025	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Trans-NIH Research Support	000	10	10/1/2024	SUPPLEMENT FOR EXPANSION	-$22,000
2025	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Trans-NIH Research Support	001	10	10/1/2024	SUPPLEMENT FOR EXPANSION	-$55,000
														Subtotal = -$109,999

Issue Date FY: 2024 ( Subtotal = $1,272,611 )
2024	2024	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	004	13	7/9/2024	NON-COMPETING CONTINUATION	$1,274,000
2024	2023	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	000	12	12/26/2023	SUPPLEMENT FOR EXPANSION	-$143,666
2024	2023	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	003	12	4/30/2024	NON-COMPETING CONTINUATION	$0
2024	2023	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	002	12	1/16/2024	NON-COMPETING CONTINUATION	$0
2024	2023	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	001	12	12/27/2023	SUPPLEMENT FOR EXPANSION	$142,277
														Subtotal = $1,272,611

Issue Date FY: 2023 ( Subtotal = $1,443,666 )
2023	2023	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	005	12	9/6/2023	SUPPLEMENT FOR EXPANSION	$143,666
2023	2023	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	004	12	7/25/2023	NON-COMPETING CONTINUATION	$1,300,000
2023	2022	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	000	11	5/5/2023	COMPETING CONTINUATION	$0
2023	2022	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Human Genome Research	003	11	5/10/2023	COMPETING CONTINUATION	$611,515
2023	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Trans-NIH Research Support	002	10	5/10/2023	SUPPLEMENT FOR EXPANSION	-$39,092
2023	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG				DEU	Trans-NIH Research Support	001	10	5/10/2023	SUPPLEMENT FOR EXPANSION	-$572,422
														Subtotal = $1,443,666

Issue Date FY: 2022 ( Subtotal = $1,519,496 )
2022	2022	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	003	11	9/1/2022	COMPETING CONTINUATION	$1,325,000
2022	2022	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Human Genome Research	004	11	9/9/2022	COMPETING CONTINUATION	$194,496
2022	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Trans-NIH Research Support	001	10	8/3/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Trans-NIH Research Support	002	10	8/3/2022	SUPPLEMENT FOR EXPANSION	$0
2022	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Trans-NIH Research Support	000	10	8/3/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,519,496

Issue Date FY: 2021 ( Subtotal = $1,095,000 )
2021	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Trans-NIH Research Support	001	10	7/6/2021	SUPPLEMENT FOR EXPANSION	$1,025,000
2021	2021	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Trans-NIH Research Support	002	10	7/7/2021	SUPPLEMENT FOR EXPANSION	$70,000
2021	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG			DEU	Trans-NIH Research Support	000	10	7/5/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,095,000

Issue Date FY: 2020 ( Subtotal = $2,487,447 )
2020	2020	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Trans-NIH Research Support	000	10	7/24/2020	NON-COMPETING CONTINUATION	$2,487,447
														Subtotal = $2,487,447

Issue Date FY: 2019 ( Subtotal = $2,575,001 )
2019	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	003	9	8/1/2019	NON-COMPETING CONTINUATION	$0
2019	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	002	9	7/23/2019	NON-COMPETING CONTINUATION	$0
2019	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	001	9	7/12/2019	NON-COMPETING CONTINUATION	$2,500,000
2019	2019	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Trans-NIH Research Support	004	9	8/21/2019	SUPPLEMENT FOR EXPANSION	$75,001
2019	2018	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	8	3/4/2019	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,575,001

Issue Date FY: 2018 ( Subtotal = $2,500,000 )
2018	2018	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	8	7/26/2018	NON-COMPETING CONTINUATION	$2,500,000
														Subtotal = $2,500,000

Issue Date FY: 2017 ( Subtotal = $2,555,156 )
2017	2017	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	001	7	7/24/2017	NON-COMPETING CONTINUATION	$2,500,000
2017	2016	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR. 1	HEIDELBERG	BADEN-WURTTEMBERG	69117		DEU	Human Genome Research	000	6	12/2/2016	COMPETING CONTINUATION	$55,156
														Subtotal = $2,555,156

Issue Date FY: 2016 ( Subtotal = $2,500,000 )
2016	2016	EUROPEAN MOLECULAR BIOLOGY LABORATORY	MEYERHOFSTR 1	HEIDELBERG				DEU	Human Genome Research	000	6	8/24/2016	COMPETING CONTINUATION	$2,500,000
														Subtotal = $2,500,000

Grand Total All Awards = $17,838,378

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Award Information

Mouse Phenotyping Informatics Infrastructure - Data acquisition, integration, analysis and translation of high throughput mammalian phenotyping data.

Award Number: UM1HG006370

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2011

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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