Sunday, August 17, 2025 8/17/2025

The BCM Knockout Mouse Production and Phenotyping Project (BCM KOMP2)

Award Number: UM1HG006348
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/16/2011
PERIOD OF PERFORMANCE END DATE: 06/30/2027

Group Awards By:

View Award Description

The BCM Knockout Mouse Production and Phenotyping Project (BCM KOMP2) - ABSTRACT The goal of the International Mouse Phenotyping Consortium (IMPC) is to develop a resource of null allele lines for every protein-coding gene in the mouse genome and, through standardized, broad-based phenotyping, catalog the biological function of each targeted gene. The NIH-funded Knockout Mouse Phenotyping Project (KOMP2) has supported two previous phases of null allele production and phenotyping, contributing to more than half of the null allele lines made and characterized by the IMPC. This application describes our plan for Baylor College of Medicine (BCM) to continue as a KOMP2 site during a third phase of funding. We propose to produce, cryopreserve, and phenotype null allele mouse lines for 600 protein coding genes. We have developed a bioinformatics approach to identify and prioritize genes with known or putative human disease associations but little-to-no in vivo functional annotation for null allele mouse line production. We will generate and validate null alleles using established CRISPR genome editing approaches and quality control procedures, cryopreserve all null allele lines using accepted techniques, and deliver germplasm to the MMRRC repositories for community- wide distribution. These null allele lines represent a gold standard resource for the scientific community and an important foundation for future research and translational studies. We will utilize our established pipelines to perform broad-based, standardized adult phenotyping on all mutant lines and assess homozygous lethal and subviable lines in an embryonic phenotyping pipeline. The phenotyping data we generate will provide fundamental new insights into mammalian biology as well as the genetic bases of human disease. All allele and phenotype data will be submitted in real time to the Data Coordination Center, ensuring the rapid dissemination of all BCM data to the wider biomedical scientific community. We will continue our production and phenotyping technology development programs, developing our own new approaches and adopting new methodologies from the community as they arise. The BCM KOMP2 team has the established expertise, experience, and resources to meet the proposed phase 3 goals in an efficient and cost-effective manner.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $2,303,000 )
2025	2025	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Human Genome Research	000	14	8/11/2025	NON-COMPETING CONTINUATION	$2,303,000
														Subtotal = $2,303,000

Issue Date FY: 2024 ( Subtotal = $2,303,000 )
2024	2024	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Human Genome Research	001	13	6/24/2024	NON-COMPETING CONTINUATION	$2,303,000
2024	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Human Genome Research	000	12	3/29/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $2,303,000

Issue Date FY: 2023 ( Subtotal = $2,519,736 )
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Human Genome Research	002	12	6/15/2023	NON-COMPETING CONTINUATION	$2,350,000
2023	2023	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Human Genome Research	003	12	9/22/2023	SUPPLEMENT FOR EXPANSION	$169,736
2023	2022	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Human Genome Research	001	11	5/10/2023	COMPETING CONTINUATION	$71,518
2023	2021	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	10	5/10/2023	SUPPLEMENT FOR EXPANSION	-$71,518
														Subtotal = $2,519,736

Issue Date FY: 2022 ( Subtotal = $2,785,667 )
2022	2022	BAYLOR COLLEGE OF MEDICINE	1 BAYLOR PLZ	HOUSTON	TX	77030	HARRIS	USA	Human Genome Research	000	11	8/22/2022	COMPETING CONTINUATION	$2,785,667
														Subtotal = $2,785,667

Issue Date FY: 2021 ( Subtotal = $2,559,904 )
2021	2021	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	003	10	9/14/2021	SUPPLEMENT FOR EXPANSION	$2,559,904
2021	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	002	10	9/14/2021	NON-COMPETING CONTINUATION	$0
2021	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	001	10	6/30/2021	NON-COMPETING CONTINUATION	$0
2021	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	10	3/25/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $2,559,904

Issue Date FY: 2020 ( Subtotal = $6,492,327 )
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	002	10	9/11/2020	SUPPLEMENT FOR EXPANSION	$397,000
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	001	10	9/10/2020	NON-COMPETING CONTINUATION	$5,851,996
2020	2020	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	003	10	9/14/2020	SUPPLEMENT FOR EXPANSION	$243,331
2020	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	9	4/1/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $6,492,327

Issue Date FY: 2019 ( Subtotal = $7,780,337 )
2019	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	002	9	8/30/2019	SUPPLEMENT FOR EXPANSION	$1,565,000
2019	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	9	8/9/2019	NON-COMPETING CONTINUATION	$5,861,046
2019	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	003	9	9/9/2019	NON-COMPETING CONTINUATION	$0
2019	2019	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Human Genome Research	001	9	8/12/2019	SUPPLEMENT FOR EXPANSION	$354,291
														Subtotal = $7,780,337

Issue Date FY: 2018 ( Subtotal = $7,372,196 )
2018	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	8	9/1/2018	NON-COMPETING CONTINUATION	$5,849,718
2018	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Human Genome Research	002	8	9/17/2018	SUPPLEMENT FOR EXPANSION	$346,613
2018	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Human Genome Research	003	8	9/18/2018	SUPPLEMENT FOR EXPANSION	$390,791
2018	2018	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Human Genome Research	001	8	9/14/2018	SUPPLEMENT FOR EXPANSION	$785,074
														Subtotal = $7,372,196

Issue Date FY: 2017 ( Subtotal = $6,563,111 )
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	004	7	9/25/2017	SUPPLEMENT FOR EXPANSION	$285,992
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	003	7	9/22/2017	SUPPLEMENT FOR EXPANSION	$104,769
2017	2017	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	002	7	8/25/2017	NON-COMPETING CONTINUATION	$5,861,046
2017	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	001	6	5/11/2017	COMPETING CONTINUATION	-$19,787
2017	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	6	3/10/2017	COMPETING CONTINUATION	$331,091
														Subtotal = $6,563,111

Issue Date FY: 2016 ( Subtotal = $4,861,046 )
2016	2016	BAYLOR COLLEGE OF MEDICINE	ONE BAYLOR PLAZA	HOUSTON	TX	77030	HARRIS	USA	Trans-NIH Research Support	000	6	9/27/2016	COMPETING CONTINUATION	$4,861,046
														Subtotal = $4,861,046

Grand Total All Awards = $45,540,324

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The BCM Knockout Mouse Production and Phenotyping Project (BCM KOMP2)

Award Number: UM1HG006348

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/16/2011

PERIOD OF PERFORMANCE END DATE: 06/30/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer