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Data Analysis Center for Somatic Mosaicism Across Human Tissues Network

Award Number: UM1DA058230
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Data Analysis Center for Somatic Mosaicism Across Human Tissues Network - PROJECT SUMMARY The goal of the Somatic Mosaicism across Human Tissues (SMaHT) Network is to better characterize the occurrence of mosaic variants in human tissues and to understand their role in the regulation of biological processes that impact health and disease. The SMaHT Data Analysis Center (DAC) aims to collect and curate all data generated in the Network; assess, develop, and apply state-of-the-art analytical pipelines; and produce a variant catalog and a data portal for the scientiﬁc community. We have assembled a team of investigators, bioinformatics scientists, data curators, and software developers with a strong track record in mosaic variant analysis, long-read data analysis, data portal development, visualization, large-scale data management and computing, and development of secure and ﬂexible cloud technologies. In Aim 1, we will work with the Network members to deﬁne data and metadata standards and ensure that high-quality data are generated, processed, and annotated uniformly and efﬁciently. In Aim 2, we will perform benchmark studies for the current tools and technologies for identiﬁcation of mosaic variants and lead an effort to deﬁne and implement analytical pipelines on a cloud platform. We will also develop new approaches as needed. We will ensure that a comprehensive set of mosaic variants of all types (single nucleotide variants, indels, copy number variants, translocations, complex rearrangements, transposable element insertions, microsatellite mutations, repeat expansions, etc.) are identiﬁed, using short- and long-read platforms, genome-wide and targeted assays, and bulk and single cell technologies. In Aim 3, we will build a user-friendly and interactive data portal containing a variant catalog and featuring a read-level variant browser to enable the scientiﬁc community to fully utilize the Network data. We will ensure that all methods and processes are documented for full reproducibility and that all tools and data are freely available to the community. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $338,988 )
2026	2026	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	002	4	5/13/2026	EXTENSION WITH OR WITHOUT FUNDS	$338,988
2026	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	000	3	2/5/2026	NON-COMPETING CONTINUATION	$0
2026	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	001	3	5/4/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $338,988

Issue Date FY: 2025 ( Subtotal = $169,495 )
2025	2025	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	002	3	7/25/2025	NON-COMPETING CONTINUATION	$169,495
2025	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	000	2	12/5/2024	NON-COMPETING CONTINUATION	$0
2025	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	001	2	12/23/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $169,495

Issue Date FY: 2024 ( Subtotal = $3,189,741 )
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	001	2	8/22/2024	SUPPLEMENT FOR EXPANSION	$207,707
2024	2024	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	000	2	5/2/2024	NON-COMPETING CONTINUATION	$2,982,034
														Subtotal = $3,189,741

Issue Date FY: 2023 ( Subtotal = $1,999,999 )
2023	2023	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	25 SHATTUCK ST	BOSTON	MA	02115	SUFFOLK	USA	Trans-NIH Research Support	000	1	4/20/2023	NEW	$1,999,999
														Subtotal = $1,999,999

Grand Total All Awards = $5,698,223

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Data Analysis Center for Somatic Mosaicism Across Human Tissues Network

Award Number: UM1DA058230

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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