Wednesday, May 8, 2024
5/8/2024
PROJECT SUMMARY/ABSTRACT This proposal organizes the resources and experience of the Cooperative Human Tissue Network Midwestern Division (CHTN MWD) for participation as an Adult Division of the NCI CHTN. Our CHTN MWD group of pathologists is equipped to efficiently provide remnant patient consented biospecimens for basic and early translational cancer research as well as for biomarker research studies to support personalized medicine. Biospecimens will also be collected under a waiver of consent for non-human subjects determined research. The Ohio State University (OSU) Hospital and James Cancer Hospital in Columbus, OH will function as the Coordinating/Procurement Center while University Hospitals Cleveland Medical Center, Cleveland, OH, and University of Pittsburgh Medical Center Shadyside, Pittsburgh, PA, and associated hospitals will function as geographically distributed Procurement/Biorepository sites. The OSU Investigator Management Service will manage the investigator applications and approvals and investigator biospecimen request networking. The OSU Biospecimen Management Service will handle the tissue Quality Control, biospecimen storage and shipping and CHTN fee billing, collections, and monthly accounting. OSU Tissue Procurement Services supports custom biospecimen collection including investigator provided novel preservation fluids or methods. Available informatics support the collection of data related to donor consents, biospecimens, investigators and billing. Shipped biospecimens include a redacted Pathology and QC Report for each biospecimen shipped. Pathology reports at OSU for freshly procured tissues include clinically appropriate molecular testing. Investigators may receive, if IRB approved, extensive clinical data available from the OSU Total Cancer Care Protocol (TCCP) Honest Broker utilizing the Information Warehouse (IW) platform and additional laboratory testing such as immunohistochemistry, tissue microarray construction, digital microscopy or digital morphometrics. Biospecimen donor privacy and confidentiality are essential elements of the CHTN MWD biospecimen management proposal so that all procured biospecimens are patient consented, unless collected under waiver of consent, and coded. Delinking is available for special tissues that were not consented at procurement. The OSU procurement program joined the OSU Comprehensive Cancer Center (OSUCCC) in deploying the TCCP in 2016 to provide comprehensive donor consent. Donors who consent give full use for future research of all their past, present and future remnant biomaterials to IRB approved researchers. Procurement/Biorepository subsites have similar consent programs in place. Scientific or technical knowledge or discoveries acquired in the conduct of our tissue procurement/preservation program will be reported at national and international scientific and technical meetings to contribute to the growth of biospecimen science, to recruit new investigators who have research interests best served by human biospecimen research and to inform the research community and public.
HHS’ Tracking Accountability in Government Grants System (TAGGS) website provides access to detailed descriptions of grants, loans, aggregated direct payments and other types of financial assistance awarded by the HHS Operating Divisions (OPDIVs) and the Office of the Secretary Staff Divisions (STAFFDIVs).
