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The Cooperative Human Tissue Network Midwestern Division (CHTN MWD)

Award Number: UM1CA239749
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/09/2019
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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The Cooperative Human Tissue Network Midwestern Division (CHTN MWD) - PROJECT SUMMARY/ABSTRACT This proposal organizes the resources and experience of the Cooperative Human Tissue Network Midwestern Division (CHTN MWD) for participation as an Adult Division of the NCI CHTN. Our CHTN MWD group of pathologists is equipped to efficiently provide remnant patient consented biospecimens for basic and early translational cancer research as well as for biomarker research studies to support personalized medicine. Biospecimens will also be collected under a waiver of consent for non-human subjects determined research. The Ohio State University (OSU) Hospital and James Cancer Hospital in Columbus, OH will function as the Coordinating/Procurement Center while University Hospitals Cleveland Medical Center, Cleveland, OH, and University of Pittsburgh Medical Center Shadyside, Pittsburgh, PA, and associated hospitals will function as geographically distributed Procurement/Biorepository sites. The OSU Investigator Management Service will manage the investigator applications and approvals and investigator biospecimen request networking. The OSU Biospecimen Management Service will handle the tissue Quality Control, biospecimen storage and shipping and CHTN fee billing, collections, and monthly accounting. OSU Tissue Procurement Services supports custom biospecimen collection including investigator provided novel preservation fluids or methods. Available informatics support the collection of data related to donor consents, biospecimens, investigators and billing. Shipped biospecimens include a redacted Pathology and QC Report for each biospecimen shipped. Pathology reports at OSU for freshly procured tissues include clinically appropriate molecular testing. Investigators may receive, if IRB approved, extensive clinical data available from the OSU Total Cancer Care Protocol (TCCP) Honest Broker utilizing the Information Warehouse (IW) platform and additional laboratory testing such as immunohistochemistry, tissue microarray construction, digital microscopy or digital morphometrics. Biospecimen donor privacy and confidentiality are essential elements of the CHTN MWD biospecimen management proposal so that all procured biospecimens are patient consented, unless collected under waiver of consent, and coded. Delinking is available for special tissues that were not consented at procurement. The OSU procurement program joined the OSU Comprehensive Cancer Center (OSUCCC) in deploying the TCCP in 2016 to provide comprehensive donor consent. Donors who consent give full use for future research of all their past, present and future remnant biomaterials to IRB approved researchers. Procurement/Biorepository subsites have similar consent programs in place. Scientific or technical knowledge or discoveries acquired in the conduct of our tissue procurement/preservation program will be reported at national and international scientific and technical meetings to contribute to the growth of biospecimen science, to recruit new investigators who have research interests best served by human biospecimen research and to inform the research community and public.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $812,212 )
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	002	7	4/4/2025	NON-COMPETING CONTINUATION	$730,970
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	003	7	5/23/2025	NON-COMPETING CONTINUATION	$81,242
2025	2024	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	6	3/18/2025	COMPETING CONTINUATION	$409
2025	2023	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	5	3/18/2025	NON-COMPETING CONTINUATION	-$409
														Subtotal = $812,212

Issue Date FY: 2024 ( Subtotal = $836,942 )
2024	2024	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	6	3/26/2024	COMPETING CONTINUATION	$836,942
														Subtotal = $836,942

Issue Date FY: 2023 ( Subtotal = $709,517 )
2023	2023	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	5	8/17/2023	NON-COMPETING CONTINUATION	$709,517
														Subtotal = $709,517

Issue Date FY: 2022 ( Subtotal = $708,567 )
2022	2022	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	4	3/31/2022	NON-COMPETING CONTINUATION	$709,517
2022	2022	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	4	4/13/2022	NON-COMPETING CONTINUATION	-$53,376
2022	2022	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	002	4	4/25/2022	NON-COMPETING CONTINUATION	$52,426
														Subtotal = $708,567

Issue Date FY: 2021 ( Subtotal = $723,996 )
2021	2021	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	001	3	3/29/2021	NON-COMPETING CONTINUATION	$723,996
2021	2020	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	2	10/20/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $723,996

Issue Date FY: 2020 ( Subtotal = $724,000 )
2020	2020	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	2	3/17/2020	NON-COMPETING CONTINUATION	$724,000
														Subtotal = $724,000

Issue Date FY: 2019 ( Subtotal = $741,681 )
2019	2019	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Cancer Detection and Diagnosis Research	000	1	4/9/2019	NEW	$741,681
														Subtotal = $741,681

Grand Total All Awards = $5,256,915

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The Cooperative Human Tissue Network Midwestern Division (CHTN MWD)

Award Number: UM1CA239749

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/09/2019

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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