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VICKtOrY Early Clinical Trials Consortium

Award Number: UM1CA186689
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/10/2014
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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VICKtOrY Early Clinical Trials Consortium - The new era in cancer drug development represents a paradigm shift in how early phase studies are conducted relative to the “conventional” approach of treating without consideration to underlying tumor genomics, biology and immunology. Translational endpoints, including levels of target expression, engagement, and modulation of downstream effectors are being assessed as early as possible, and increasing emphasis is being placed on early patient selection, utilizing novel biomarker assays and molecular characterization to identify patients most likely to respond. The ultimate purpose of the NCI Experimental Therapeutics-Clinical Trials Network (ETCTN) is to develop new therapeutic options while also defining better approaches for the development of novel anticancer agents that capitalize on the ability to characterize tumors molecularly and by also finding appropriate biomarkers to select patients most likely to respond. As biomarker-driven trials become the cornerstone of early phase investigation, allowing for the study of potential mechanisms of response and resistance, incorporation of these biomarkers is lending itself to novel trial designs which incorporate fewer, and often rarer patient subsets, defining greater patient outcomes with smaller recruited populations. As a result, a unique network such as the ETCTN, consisting of multiple scientifically-driven sites and investigators with a vast array of expertise, is needed. The ETCTN allows investigators to test relevant bench-to-bedside findings, and through integrated analysis and the development of interdisciplinary teams, incorporates reverse translation to bring the bedside back to the bench. This application is a re-competition of our previous ETCTN UM1 award (1UM1CA186689), demonstrating both our progress over the past funding period as well as our capabilities to conduct early phase clinical trials. We have slightly amended our original partnerships which now include Vanderbilt-Ingram, University of California San Diego, Karmanos Cancer Institute, University of Oklahoma Stephenson Cancer Center (new) and the Yale Cancer Center (VICKtOrY). Our team aims to 1) leverage novel scientific discoveries for translation into early phase trials, using the CTEP pharmacopeia, in rare cancers, common cancers, and uncommon variants of common cancers; 2) incorporate serum, tissue and imaging biomarkers to better understand the effects of novel agents either alone or in combination; 3) train early career investigators to be knowledgeable and proficient in conducting early phase clinical trials by providing clinical research leadership opportunities and mentoring; and 4) include as a component of our early phase clinical trial recruitment, no less than 10% underserved/special populations. The members of our team have a unique set of complementary expertise and a similar philosophy regarding collaborative research and mentorship of the next generation of cancer investigators. VICKtOrY is committed to utilizing our areas of expertise, integrating the science at our institutions, and maximizing our collaborative relationships to conduct cutting-edge early phase trials within the ETCTN with the ultimate mission of improving outcomes for cancer patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,041,538 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	000	9	3/20/2025	NON-COMPETING CONTINUATION	$1,041,538
														Subtotal = $1,041,538

Issue Date FY: 2024 ( Subtotal = $1 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	005	8	5/22/2024	NON-COMPETING CONTINUATION	$1
2024	2023	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	004	7	2/15/2024	EXTENSION WITH OR WITHOUT FUNDS	$2,392,009
2024	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	000	7	10/11/2023	EXTENSION WITH OR WITHOUT FUNDS	$0
2024	2022	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	003	6	2/15/2024	SUPPLEMENT FOR EXPANSION	-$587,757
2024	2021	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	002	6	2/15/2024	SUPPLEMENT FOR EXPANSION	-$331,885
2024	2020	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	001	6	2/15/2024	COMPETING CONTINUATION	-$1,472,367
														Subtotal = $1

Issue Date FY: 2023 ( Subtotal = $2,044,455 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	001	7	9/20/2023	EXTENSION WITH OR WITHOUT FUNDS	$340,794
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	000	7	5/30/2023	EXTENSION WITH OR WITHOUT FUNDS	$1,703,661
														Subtotal = $2,044,455

Issue Date FY: 2022 ( Subtotal = $587,757 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	003	6	9/7/2022	SUPPLEMENT FOR EXPANSION	$500,000
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	002	6	8/31/2022	SUPPLEMENT FOR EXPANSION	$87,757
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	001	6	11/22/2021	SUPPLEMENT FOR EXPANSION	$0
2022	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	000	6	11/22/2021	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $587,757

Issue Date FY: 2021 ( Subtotal = $331,885 )
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	001	6	6/25/2021	SUPPLEMENT FOR EXPANSION	$108,302
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	000	6	6/17/2021	SUPPLEMENT FOR EXPANSION	$123,583
2021	2021	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	002	6	7/8/2021	SUPPLEMENT FOR EXPANSION	$100,000
														Subtotal = $331,885

Issue Date FY: 2020 ( Subtotal = $7,379,439 )
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	004	6	9/8/2020	COMPETING CONTINUATION	$330,083
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	000	6	5/1/2020	COMPETING CONTINUATION	$6,292,877
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	005	6	9/16/2020	COMPETING CONTINUATION	$228,075
2020	2020	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	001	6	6/23/2020	COMPETING CONTINUATION	$858,487
2020	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	003	5	9/8/2020	SUPPLEMENT FOR EXPANSION	-$119,227
2020	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	002	5	9/8/2020	NON-COMPETING CONTINUATION	-$210,856
														Subtotal = $7,379,439

Issue Date FY: 2019 ( Subtotal = $2,033,669 )
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	004	5	6/18/2019	NON-COMPETING CONTINUATION	$83,750
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	002	5	4/8/2019	SUPPLEMENT FOR EXPANSION	$119,227
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	003	5	5/21/2019	NON-COMPETING CONTINUATION	$421,177
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	001	5	4/1/2019	NON-COMPETING CONTINUATION	$0
2019	2019	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	000	5	3/18/2019	NON-COMPETING CONTINUATION	$1,409,515
														Subtotal = $2,033,669

Issue Date FY: 2018 ( Subtotal = $1,325,865 )
2018	2018	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	000	4	3/1/2018	NON-COMPETING CONTINUATION	$1,325,865
														Subtotal = $1,325,865

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	001	3	3/15/2017	SUPPLEMENT FOR EXPANSION	$0
2017	2016	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Cancer Treatment Research	000	3	3/15/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $2,262,327 )
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Treatment Research	003	3	8/18/2016	NON-COMPETING CONTINUATION	$214,734
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Treatment Research	002	3	7/29/2016	SUPPLEMENT FOR EXPANSION	$167,500
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Treatment Research	000	3	4/19/2016	NON-COMPETING CONTINUATION	$812,725
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Treatment Research	004	3	9/9/2016	NON-COMPETING CONTINUATION	$335,000
2016	2016	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Treatment Research	001	3	4/25/2016	SUPPLEMENT FOR EXPANSION	$732,368
														Subtotal = $2,262,327

Issue Date FY: 2015 ( Subtotal = $1,535,152 )
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Treatment Research	001	2	8/31/2015	NON-COMPETING CONTINUATION	$54,684
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Treatment Research	000	2	4/8/2015	NON-COMPETING CONTINUATION	$817,287
2015	2015	YALE UNIVERSITY	47 College Street	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Cancer Treatment Research	002	2	9/4/2015	NON-COMPETING CONTINUATION	$663,181
														Subtotal = $1,535,152

Issue Date FY: 2014 ( Subtotal = $1,420,000 ) (Continued on the next page)
Grand Total All Awards = $19,962,088

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VICKtOrY Early Clinical Trials Consortium

Award Number: UM1CA186689

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/10/2014

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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