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Tennessee Valley Cooperative Human Tissue Network

Award Number: UM1CA183727
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2014
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Tennessee Valley Cooperative Human Tissue Network - PROJECT SUMMARY The Cooperative Human Tissue Network (CHTN) has played an important role since 1987 as a source of human tissues for biomedical research. To this end, the overarching goal of the Western Division of the CHTN at Vanderbilt University Medical Center (CHTN-VUMC) is to continue to serve the scientific community by procuring and distributing adult biospecimens, utilizing a stringent quality management program to maintain a highly efficient and productive biorepository operation. Key aspects of this goal are the prospective customized collection of high-quality solid tissues and biofluids with clinical annotation and the application of a rigorous Quality Management System to all aspects of the program. Services include blood and biofluid collection (whole vacutainers) including investigator-supplied tubes and specialized procurement of fresh tissue for Tumor Infiltrating Lymphocytes (TILs) in response to changing investigator needs are proposed. In addition, preneoplastic and rare lesions will be banked to facilitate research in tumor progression. The CHTN-VUMC will adhere to rigorous ethical standards for protection of human subjects and patient confidentiality and will partner with the VUMC advocacy program to engage patients and provide opportunities for participation in research. We also propose to serve as the Informatics (IT) trans-network Coordinating Center responsible for the second version of the “Investigators IT” system (TQII), utilizing web services (AWS hosted) and a strong modern technologically advanced platform and ensuring adherence to IT security best practices. In its divisional IT strategy, CHTN-VUMC will develop and integrate new business models and novel informatics strategies to improve operational efficiency. Marketing efforts will include initiatives to increase awareness of CHTN in the scientific community, including enhanced use of social media, and CHTN-VUMC will actively contribute to biorepository science and education through leadership in societies such as the International Society for Biological and Environmental Repositories. CHTN-VUMC’s leadership in network IT development makes the division uniquely qualified to continue serving as the central IT coordinating site. A robust track record of specimen procurement and distribution, with 57,977 specimens shipped to 734 investigators over the past 5 years, highlights the capabilities of the existing CHTN-VUMC infrastructure. CHTN-VUMC goals in the next funding period include building upon these foundational achievements to improve efficiency and communication within the network, investigators and scientific community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,024,217 )
2025	2025	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	002	13	5/28/2025	NON-COMPETING CONTINUATION	$105,002
2025	2025	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	001	13	3/11/2025	NON-COMPETING CONTINUATION	$919,215
2025	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	11	2/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,024,217

Issue Date FY: 2024 ( Subtotal = $1,075,380 )
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	12	3/20/2024	COMPETING CONTINUATION	$1,075,380
														Subtotal = $1,075,380

Issue Date FY: 2023 ( Subtotal = $861,102 )
2023	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	11	3/21/2023	NON-COMPETING CONTINUATION	$861,102
														Subtotal = $861,102

Issue Date FY: 2022 ( Subtotal = $868,395 )
2022	2022	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	10	2/21/2022	NON-COMPETING CONTINUATION	$796,430
2022	2022	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	001	10	5/25/2022	NON-COMPETING CONTINUATION	$71,965
														Subtotal = $868,395

Issue Date FY: 2021 ( Subtotal = $912,831 )
2021	2021	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	9	3/26/2021	NON-COMPETING CONTINUATION	$912,831
														Subtotal = $912,831

Issue Date FY: 2020 ( Subtotal = $912,750 )
2020	2020	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	8	3/26/2020	NON-COMPETING CONTINUATION	$912,750
														Subtotal = $912,750

Issue Date FY: 2019 ( Subtotal = $956,176 )
2019	2019	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	7	3/22/2019	COMPETING CONTINUATION	$956,176
2019	2019	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	002	7	7/1/2019	COMPETING CONTINUATION	$13,130
2019	2018	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	001	6	7/1/2019	NON-COMPETING CONTINUATION	-$13,130
														Subtotal = $956,176

Issue Date FY: 2018 ( Subtotal = $986,029 )
2018	2018	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	6	4/4/2018	NON-COMPETING CONTINUATION	$986,029
														Subtotal = $986,029

Issue Date FY: 2017 ( Subtotal = $988,984 )
2017	2017	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	001	5	6/6/2017	NON-COMPETING CONTINUATION	$112,029
2017	2017	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	5	3/22/2017	NON-COMPETING CONTINUATION	$876,955
														Subtotal = $988,984

Issue Date FY: 2016 ( Subtotal = $982,724 )
2016	2016	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	001	3	5/6/2016	NON-COMPETING CONTINUATION	-$900,830
2016	2016	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	3	3/21/2016	NON-COMPETING CONTINUATION	$982,724
2016	2016	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	002	4	5/6/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$900,830
														Subtotal = $982,724

Issue Date FY: 2015 ( Subtotal = $982,724 )
2015	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	2	3/2/2015	NON-COMPETING CONTINUATION	$982,724
														Subtotal = $982,724

Issue Date FY: 2014 ( Subtotal = $981,160 )
2014	2014	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Cancer Detection and Diagnosis Research	000	1	4/1/2014	NEW	$981,160
														Subtotal = $981,160

Grand Total All Awards = $11,532,472

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Tennessee Valley Cooperative Human Tissue Network

Award Number: UM1CA183727

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2014

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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