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Breast Cancer Family Registry Cohort

Award Number: UM1CA164920
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/12/2012
PERIOD OF PERFORMANCE END DATE: 04/30/2018

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Breast Cancer Family Registry Cohort - DESCRIPTION (provided by applicant): The objective of this UM1 application is to maintain and enhance the core infrastructure of the Breast Cancer Family Registry (BCFR), an international resource of multi-generational families established for interdisciplinary collaborative research on breast cancer. The BCFR Cohort, established in 1995 at 6 sites is comprised of 34,000 individuals from 11,900 families who provided data on family history and epidemiologic risk factors as well as bio specimens. Over the next five years, the BCFR investigator team will continue 1) to actively follow the family cohort using common instruments and protocols, update the cancer family histories to identify new breast and other cancers in the families, and administer a follow-up questionnaire to update baseline epidemiologic data; 2) to maintain the extensive data and bio specimen resources and enhance them by conducting pathology review for all new breast cancers ascertained since baseline, completing molecular sub typing of tumors, and completing genotyping of known common breast cancer susceptibility variants; 3) to collect new data on screening, uptake of risk reductive and preventive health behaviors, knowledge of genetic disease, and uptake of genetic testing and communication to family members that will facilitate the translation of findings into clinical practice; and 4) to continue and expand collaborations with external investigators by sharing of BCFR data and bio specimen resources for a wide range of studies of gene discovery, cancer-related outcomes, risk factors in high-risk individuals, behavioral interventions and cancer prevention trials among at-risk family members. The BCFR Cohort is unique in that it is family-based and the first large prospective study of breast cancer risk for women at a continuum of risk. In addition to the unaffected cohort, the BCFR has one of the largest affected cohorts and will therefore provide a powerful resource for translational and clinical studies of recurrences, second primaries and survival.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$201,997 )
2023	2017	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVE STE 300	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	000	5	10/1/2022	SUPPLEMENT FOR EXPANSION	-$132,778
2023	2017	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVE STE 300	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	001	5	10/1/2022	SUPPLEMENT FOR EXPANSION	-$69,219
														Subtotal = -$201,997

Issue Date FY: 2018 ( Subtotal = -$22,543 )
2018	2017	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVE STE 300	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	001	5	3/29/2018	SUPPLEMENT FOR EXPANSION	$0
2018	2017	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVE STE 300	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	002	5	9/27/2018	SUPPLEMENT FOR EXPANSION	-$22,543
2018	2016	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVE STE 300	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	000	5	3/28/2018	EXTENSION WITH OR WITHOUT FUNDS	$0
														Subtotal = -$22,543

Issue Date FY: 2017 ( Subtotal = $91,762 )
2017	2017	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVE STE 300	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	002	5	3/9/2017	SUPPLEMENT FOR EXPANSION	$91,762
2017	2016	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVE STE 300	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	001	5	1/31/2017	EXTENSION WITH OR WITHOUT FUNDS	$427,763
2017	2015	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVE STE 300	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	000	4	1/31/2017	NON-COMPETING CONTINUATION	-$427,763
														Subtotal = $91,762

Issue Date FY: 2016 ( Subtotal = $2,519,194 )
2016	2016	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVENUE	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	000	5	8/25/2016	EXTENSION WITH OR WITHOUT FUNDS	$2,519,194
														Subtotal = $2,519,194

Issue Date FY: 2015 ( Subtotal = $2,567,967 )
2015	2015	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVENUE	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	000	4	8/28/2015	NON-COMPETING CONTINUATION	$2,567,967
														Subtotal = $2,567,967

Issue Date FY: 2014 ( Subtotal = $2,489,620 )
2014	2014	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVENUE	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	000	3	8/25/2014	NON-COMPETING CONTINUATION	$2,489,620
														Subtotal = $2,489,620

Issue Date FY: 2013 ( Subtotal = $2,258,395 )
2013	2013	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVENUE	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	000	2	8/29/2013	NON-COMPETING CONTINUATION	$2,258,395
														Subtotal = $2,258,395

Issue Date FY: 2012 ( Subtotal = $2,723,075 )
2012	2012	CANCER PREVENTION INSTITUTE OF CALIFORNIA	2201 WALNUT AVENUE	FREMONT	CA	94538	ALAMEDA	USA	Cancer Cause and Prevention Research	000	1	9/12/2012	NEW	$2,723,075
														Subtotal = $2,723,075

Grand Total All Awards = $12,425,473

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Breast Cancer Family Registry Cohort

Award Number: UM1CA164920

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/12/2012

PERIOD OF PERFORMANCE END DATE: 04/30/2018

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