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New Horizons in the Prevention and Treatment of Food Allergy

Award Number: UM1AI182034
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/04/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2031

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New Horizons in the Prevention and Treatment of Food Allergy - Leadership Center Summary/Abstract Food allergy research has increased dramatically over the past 20 years, in large part to the efforts of CoFAR. New approaches for both treatment and prevention have been introduced, as have the understanding of the immunologic basis of food allergy. The overarching goal of the research agenda proposed in this application is to maintain CoFAR's position as an international leader in the study of food allergy, including optimal characterization of the disease and development of the next generation of treatments ad prevention. The research agenda will be based first and foremost on the best possible science, but to maximize productivity we will also need to plan judiciously so that all available resources can be used to their utmost capacity. Therefore, the research agenda will need to carefully select and stage protocols based not just on their potential to advance the field, but also with careful consideration regarding other novel treatments that may be under development, and how one study may inform the next. Finally, the overall research strategy will need to work in unison with the NIAID, the SACCC and each CRC in the consortium. This overall agenda will be accomplished through the following major components: 1) To implement a leadership team capable of providing optimal administration of the Consortium, including financial, operational, and managerial aspects, as well as protocol development and implementation, data collection and analysis, and publications and presentations, with judicious financial management. Dr. Robert Wood will lead this team, with co-PIs Drs. Scott Sicherer and Supinda Bunyavanich. The team will include experts in clinical trials as well as the laboratory study of food allergy. The team will also include a financial administrator as well as a highly experienced grants management group at Johns Hopkins. The leadership team will work closely with the NIAID and SACCC, together providing day-to-day management of all clinical operations within the consortium. 2) To develop the necessary committee structure to guide and implement the Consortium's administrative and clinical operations. 3) To develop a structure of financial management that will make optimal use of all CoFAR funds and resources. 4) To integrate the Biomarker Facility into each clinical protocol. It is anticipated that a minimum of 2 major protocols, including both clinical trials and non-interventional studies, will be initiated and completed over the seven-year funding period, and this could rise to 4 or even 5 protocols depending on the size, duration, and complexity of each study. If successful, this research agenda will define not just the next 7 years of CoFAR, but will also establish the platform for the next decade(s) of food allergy research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $7,299,172 )
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	3	3/24/2026	NON-COMPETING CONTINUATION	$7,299,172
														Subtotal = $7,299,172

Issue Date FY: 2025 ( Subtotal = $12,861,502 )
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	001	2	8/21/2025	SUPPLEMENT FOR EXPANSION	$5,561,502
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	2	5/2/2025	NON-COMPETING CONTINUATION	$7,300,000
														Subtotal = $12,861,502

Issue Date FY: 2024 ( Subtotal = $13,100,000 )
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	000	1	4/4/2024	NEW	$7,300,000
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	002	1	9/10/2024	SUPPLEMENT FOR EXPANSION	$0
2024	2024	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Allergy and Infectious Diseases Research	001	1	7/29/2024	SUPPLEMENT FOR EXPANSION	$5,800,000
														Subtotal = $13,100,000

Grand Total All Awards = $33,260,674

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New Horizons in the Prevention and Treatment of Food Allergy

Award Number: UM1AI182034

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/04/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2031

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