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Botswana-Harvard T.H. Chan School of Public Health AIDS Initiative Partnership CTU

Award Number: UM1AI069456
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Summary/Abstract This is an application to renew a Clinical Trials Unit (CTU) in Botswana that will conduct research related to adult and pediatric HIV therapeutic strategies; interventions to address HIV-associated infections/conditions in pediatric and maternal populations; treatment and prevention of tuberculosis in adults (including pregnant women) and children with and without HIV; and integrated HIV prevention strategies in pediatric and adult populations. These activities will occur through participation in three research networks: 1) the HIV/AIDS Adult Therapeutics Clinical Trials Network; 2) HIV/AIDS Maternal, Adolescent and Pediatric Therapeutics Clinical Trials Network, and 3) the HIV Prevention Clinical Trials Network. We will perform multi-center studies at our two established CRSs: one in Gaborone (all 3 networks), the capital city of Botswana, and the other in Molepolole (Maternal, Adolescent and Pediatric Therapeutics network only), the largest village in Botswana. We will thus work with both urban and village populations of all ages and of both sexes. The primary objective of this proposal is therefore to renew a CTU in Botswana that will participate in and contribute to the following high-impact areas of research: ¿ Novel and durable treatments for HIV in adults (including pregnant women) and children ¿ Strategies to induce ART-free HIV remission (or eradication) in adults and children ¿ Treatment and prevention of HIV-related complications and co-infections in adults and children ¿ New treatments / modalities and prevention approaches for tuberculosis in adults and children ¿ HIV prevention strategies, including pre-exposure prophylaxis and integrated prevention approaches Within each of these research areas, this CTU will contribute significantly to: ¿ Enrolling participants into and conducting high-quality clinical research studies, ¿ Participating in network activities, including protocol teams and scientific / resource committees, and ¿ Conceiving and proposing new, relevant, high-impact studies in priority areas


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $949,067 )
2024	2024	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	18	11/8/2023	NON-COMPETING CONTINUATION	$949,067
														Subtotal = $949,067

Issue Date FY: 2023 ( Subtotal = $1,861,341 )
2023	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	17	11/23/2022	NON-COMPETING CONTINUATION	$930,671
2023	2023	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	17	6/23/2023	NON-COMPETING CONTINUATION	$930,670
														Subtotal = $1,861,341

Issue Date FY: 2022 ( Subtotal = $1,932,439 )
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	16	6/10/2022	NON-COMPETING CONTINUATION	$753,651
2022	2022	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	16	11/30/2021	NON-COMPETING CONTINUATION	$1,178,788
2022	2022	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	004	16	7/21/2022	NON-COMPETING CONTINUATION	$0
2022	2021	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	003	15	6/10/2022	COMPETING CONTINUATION	$9,968
2022	2020	HARVARD COLLEGE PRESIDENT & FELLOWS OF	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	14	6/10/2022	NON-COMPETING CONTINUATION	-$9,968
														Subtotal = $1,932,439

Issue Date FY: 2021 ( Subtotal = $1,941,572 )
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	15	11/27/2020	COMPETING CONTINUATION	$970,786
2021	2021	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	15	6/3/2021	COMPETING CONTINUATION	$970,786
2021	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	14	5/27/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $1,941,572

Issue Date FY: 2020 ( Subtotal = $2,310,807 )
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	14	11/21/2019	NON-COMPETING CONTINUATION	$1,155,404
2020	2020	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	14	5/29/2020	NON-COMPETING CONTINUATION	$1,155,403
														Subtotal = $2,310,807

Issue Date FY: 2019 ( Subtotal = $2,702,555 )
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	13	11/19/2018	NON-COMPETING CONTINUATION	$1,310,095
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	13	8/21/2019	NON-COMPETING CONTINUATION	$0
2019	2019	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	13	5/13/2019	NON-COMPETING CONTINUATION	$1,392,460
														Subtotal = $2,702,555

Issue Date FY: 2018 ( Subtotal = $1,570,005 )
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	003	12	8/30/2018	NON-COMPETING CONTINUATION	$203,701
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	12	11/28/2017	NON-COMPETING CONTINUATION	$455,435
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	12	5/11/2018	NON-COMPETING CONTINUATION	$683,152
2018	2018	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	12	2/13/2018	NON-COMPETING CONTINUATION	$227,717
														Subtotal = $1,570,005

Issue Date FY: 2017 ( Subtotal = $1,122,839 )
2017	2017	PRESIDENT AND FELLOWS OF HARVARD COLLEGE	677 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	11	11/14/2016	NON-COMPETING CONTINUATION	$1,122,839
														Subtotal = $1,122,839

Issue Date FY: 2016 ( Subtotal = $1,198,312 )
2016	2016	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	10	8/9/2016	NON-COMPETING CONTINUATION	$75,198
2016	2016	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	10	11/10/2015	NON-COMPETING CONTINUATION	$1,123,114
														Subtotal = $1,198,312

Issue Date FY: 2015 ( Subtotal = $1,235,184 )
2015	2015	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	9	6/11/2015	NON-COMPETING CONTINUATION	$100,000
2015	2015	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	9	8/14/2015	NON-COMPETING CONTINUATION	$117,522
2015	2015	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	9	11/21/2014	NON-COMPETING CONTINUATION	$1,017,662
														Subtotal = $1,235,184

Issue Date FY: 2014 ( Subtotal = $2,382,602 )
2014	2014	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	002	8	2/20/2014	COMPETING CONTINUATION	$236,721
2014	2014	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	001	8	12/26/2013	COMPETING CONTINUATION	$1,289,227
2014	2014	HARVARD UNIVERSITY, SCHOOL OF PUBLIC HEALTH	55 SHATTUCK STREET	BOSTON	MA	02115	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	8	12/10/2013	COMPETING CONTINUATION	$856,654
														Subtotal = $2,382,602

Issue Date FY: 2013 ( Subtotal = $2,200,921 )
2013	2013	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	7	11/29/2012	NON-COMPETING CONTINUATION	$2,006,945
2013	2013	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	7	6/7/2013	NON-COMPETING CONTINUATION	$193,976
														Subtotal = $2,200,921

Issue Date FY: 2012 ( Subtotal = $2,772,513 )
2012	2012	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Allergy and Infectious Diseases Research	000	6	12/21/2011	NON-COMPETING CONTINUATION	$2,154,202
2012	2012	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Allergy and Infectious Diseases Research	003	6	7/3/2012	NON-COMPETING CONTINUATION	$247,456
2012	2012	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Allergy and Infectious Diseases Research	002	6	6/27/2012	NON-COMPETING CONTINUATION	$104,255
2012	2012	HARVARD UNIVERSITY PRESIDENT & FELLOWS	HOLYOKE 466, 1350 MASS AVENUE	CAMBRIDGE	MA	02138	MIDDLESEX	USA	Allergy and Infectious Diseases Research	001	6	1/30/2012	NON-COMPETING CONTINUATION	$266,600
														Subtotal = $2,772,513

Grand Total All Awards = $24,180,157

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Botswana-Harvard T.H. Chan School of Public Health AIDS Initiative Partnership CTU

Award Number: UM1AI069456

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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