Saturday, November 23, 2024 11/23/2024

UZ-UCSF CTU

Award Number: UM1AI069436
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: COOPERATIVE AGREEMENT
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract For over 2 decades the University of Zimbabwe-University of California, San Francisco Clinical Trials Unit (UZ- UCSF CTU) has continuously conducted high quality Phase I-IV clinical trials, utilizing experienced teams of multidisciplinary, cross-trained investigators, and research staff across the multi-Network CTU. The CTU is a center of excellence in the prevention and control of HIV/AIDS and has contributed to the global understanding of HIV epidemiology and pathogenesis, policy, and standards of care. In the current funding cycle, the CTU enrolled over 6,700 participants in 48 clinical trials across all 5 NIH-funded Networks (ACTG, IMPAACT, HPTN, HVTN, MTN) at 7 Clinical Research Sites (CRSs), generating 138 scientific articles and informing Zimbabwe’s health policy. The CTU has innovated to overcome operational challenges occasioned by the political and economic environment in Zimbabwe. The CTU proposes to continue to develop its scientifically rigorous and well-managed CTU to support the scientific agendas of the 4 proposed Networks (ACTG, IMPAACT, HPTN, HVTN), train the next generation of research leaders in Zimbabwe, and contribute to the control and prevention of HIV and TB in Zimbabwe and globally, with 4 Specific Aims: Specific Aim 1. Lead robust contributions to the research agendas of the ACTG, IMPAACT, HPTN, HVTN Networks; a) Continue to advance evaluation of novel and durable systemic ARV-based therapeutic and preventive strategies for: (i) control of HIV replication in the absence of ART; (ii) control of communicable and non-communicable comorbidities; and (iii) prevention of HIV in Key Populations, including adolescent girls and young women, men who have sex with men, and female sex workers by evaluating novel PrEP drug delivery systems; b) Continue evaluation of novel preventative and therapeutic vaccine candidates and broadly neutralizing antibodies for HIV/TB control among children, adolescents, and adults; c) Implement integrated strategies to evaluate socio- behavioral, biomedical, and structural interventions for HIV prevention among high-risk Key Populations while optimizing treatment outcomes among children, adolescents, and adults living with HIV; d) Investigate new product acceptability, uptake, and adherence using mixed methods to assess the effectiveness of novel approaches, including Multi-Purpose Prevention Technologies; Specific Aim 2. Intensify community engagement at all stages of research and evolve Community Advisory Board membership to represent, mobilize, and empower Key Populations, in support of the UNAIDS 95-95-95 targets; Specific Aim 3. Maintain and adapt our CTU’s efficient and sophisticated centralized research infrastructures across the CRSs and the Laboratory, Pharmacy, Community, Regulatory, Quality Management, Administration and Finance Departments to drive compliance and ensure efficient execution of trials; and Specific Aim 4. Fortify the CTU’s role as a local, regional, and global knowledge hub with investments in training and mentorship for the next generation of scientific and community-based leaders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $1,604,421 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	19	11/12/2024	NON-COMPETING CONTINUATION	$1,801,834
2025	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	14	10/1/2024	NON-COMPETING CONTINUATION	-$197,413
														Subtotal = $1,604,421

Issue Date FY: 2024 ( Subtotal = $3,766,515 )
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	003	18	6/18/2024	NON-COMPETING CONTINUATION	$0
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	18	11/1/2023	NON-COMPETING CONTINUATION	$1,835,781
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	18	6/12/2024	SUPPLEMENT FOR EXPANSION	$98,504
2024	2024	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	18	6/12/2024	NON-COMPETING CONTINUATION	$1,832,230
														Subtotal = $3,766,515

Issue Date FY: 2023 ( Subtotal = $4,765,421 )
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	17	6/5/2023	NON-COMPETING CONTINUATION	$2,388,574
2023	2023	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	17	11/14/2022	NON-COMPETING CONTINUATION	$2,316,595
2023	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	15	7/5/2023	COMPETING CONTINUATION	$60,252
														Subtotal = $4,765,421

Issue Date FY: 2022 ( Subtotal = $5,312,671 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	16	11/15/2021	NON-COMPETING CONTINUATION	$3,047,212
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	16	12/7/2021	NON-COMPETING CONTINUATION	$0
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	003	16	6/17/2022	NON-COMPETING CONTINUATION	$317,241
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	16	6/3/2022	NON-COMPETING CONTINUATION	$1,948,218
														Subtotal = $5,312,671

Issue Date FY: 2021 ( Subtotal = $4,041,794 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	15	11/20/2020	COMPETING CONTINUATION	$2,319,532
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	004	15	5/20/2021	COMPETING CONTINUATION	$0
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	15	2/26/2021	COMPETING CONTINUATION	$1,782,514
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	003	14	5/14/2021	NON-COMPETING CONTINUATION	$0
2021	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	14	4/6/2021	NON-COMPETING CONTINUATION	-$60,252
														Subtotal = $4,041,794

Issue Date FY: 2020 ( Subtotal = $8,030,499 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	14	2/14/2020	NON-COMPETING CONTINUATION	$0
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	14	11/21/2019	NON-COMPETING CONTINUATION	$4,015,250
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	14	5/19/2020	NON-COMPETING CONTINUATION	$4,015,249
														Subtotal = $8,030,499

Issue Date FY: 2019 ( Subtotal = $10,064,529 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	003	13	8/13/2019	NON-COMPETING CONTINUATION	$682,884
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	13	5/15/2019	NON-COMPETING CONTINUATION	$4,699,058
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	13	2/28/2019	NON-COMPETING CONTINUATION	$0
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	13	11/21/2018	NON-COMPETING CONTINUATION	$4,682,587
														Subtotal = $10,064,529

Issue Date FY: 2018 ( Subtotal = $3,469,957 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	12	5/10/2018	NON-COMPETING CONTINUATION	$1,357,089
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	12	2/9/2018	NON-COMPETING CONTINUATION	$801,483
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	003	12	7/31/2018	NON-COMPETING CONTINUATION	$232,099
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	12	11/29/2017	NON-COMPETING CONTINUATION	$1,079,286
														Subtotal = $3,469,957

Issue Date FY: 2017 ( Subtotal = $3,210,348 )
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	11	11/11/2016	NON-COMPETING CONTINUATION	$3,165,328
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	11	5/15/2017	NON-COMPETING CONTINUATION	$45,020
2017	2017	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	11	1/30/2017	NON-COMPETING CONTINUATION	$0
														Subtotal = $3,210,348

Issue Date FY: 2016 ( Subtotal = $2,602,648 )
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	10	6/27/2016	NON-COMPETING CONTINUATION	$107,016
2016	2016	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	10	11/13/2015	NON-COMPETING CONTINUATION	$2,495,632
														Subtotal = $2,602,648

Issue Date FY: 2015 ( Subtotal = $2,526,785 )
2015	2015	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	002	9	8/20/2015	NON-COMPETING CONTINUATION	$65,757
2015	2015	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	9	11/17/2014	NON-COMPETING CONTINUATION	$2,181,278
2015	2015	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	001	9	6/26/2015	NON-COMPETING CONTINUATION	$279,750
														Subtotal = $2,526,785

Issue Date FY: 2014 ( Subtotal = $6,980,494 ) (Continued on the next page)
2014	2014	UNIVERSITY OF CALIFORNIA-SAN FRANCISCO	BOX 0812	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Allergy and Infectious Diseases Research	000	8	12/10/2013	COMPETING CONTINUATION	$1,761,200
Grand Total All Awards = $68,031,038

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UZ-UCSF CTU

Award Number: UM1AI069436

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: COOPERATIVE AGREEMENT

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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